Molecular testing in endometrial carcinoma – joint recommendation of Czech Oncological Society, Oncogynecological Section of the Czech Gynecological and Obstetrical Society, Society of Radiation Oncology, Biology and Physics, and the Society of Czech Pathologists

Czech version

Authors: Dundr P. ¹; Cibula D. ²; Doležel M. ³; Fabián P. ⁴; Fínek J. ⁵; Jirásek T. ⁶; Matěj R. ^1,7,8; L. Petruželka ⁹; Rob L. ¹⁰; Ryška A. ¹¹; Švajdler M. ^12,13; Weinberger V. ¹⁴; Zikán M. ¹⁵
Authors‘ workplace: Ústav patologie, 1. LF UK a VFN v Praze ¹; Onkogynekologické centrum, Gynekologicko-porodnická klinika 1. LF UK a VFN v Praze ²; Onkologická klinika LF UP a FN Olomouc ³; Oddělení onkologické patologie, MOÚ Brno ⁴; Onkologická a radioterapeutická klinika LF UK a FN Plzeň ⁵; Oddělení patologie, Centrum PATOS, Krajská nemocnice Liberec, a. s. ⁶; Ústav patologie, 3. LF UK a FN Královské Vinohrady, Praha ⁷; Ústav patologie a molekulární medicíny, 3. LF UK a FTN Praha ⁸; Onkologická klinika 1. LF UK a VFN v Praze ⁹; Gynekologicko-porodnická klinika 3. LF UK a FN Královské Vinohrady, Praha ¹⁰; Fingerlandův ústav patologie, LF UK a FN Hradec Králové ¹¹; Šiklův ústav patologie, LF UK a FN Plzeň ¹²; Bioptická laboratoř, s. r. o., Plzeň ¹³; Gynekologicko-porodnická klinika LF MU a FN Brno ¹⁴; Gynekologicko-porodnická klinika 1. LF UK a FN Bulovka, Praha ¹⁵
Published in: Ceska Gynekol 2021; 86(4): 264-272
Category:
doi: https://doi.org/10.48095/cccg2021264

Overview

Molecular classification of endometrial carcinoma is becoming an important part of the diagnostic process with direct therapeutic implications. Recent international guidelines, including the joint recommendation of the European Society of Gynaecological Oncology, the European Society for Radiotherapy and Oncology and the European Society of Pathology include the molecular classification into standard diagnostic algorithms. Molecular testing of endometrial carcinomas is also recommended in the latest (5^th edition) of the World Health Organization classification of female genital tumors. Due to the need to implement these recommendations in practice, representatives of four professional societies of the Czech Medical Association of J. E. Purkyně (the Czech Oncological Society, the Oncogynecological Section of the Czech Gynecological and Obstetrical Society, the Society of Radiation Oncology, Biology and Physics, and the Society of Czech Pathologists) organized a meeting focused on this topic. Recommendation for molecular testing of endometrial carcinoma in routine diagnostic practice in the Czech Republic.

Keywords:

Endometrial carcinoma – molecular testing – POLE (DNA polymerase epsilon) – mismatch repair system – p53

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Article was published in

Czech Gynaecology

2021 Issue 4