Lactobacillus crispatus dominant vaginal microbita in pregnancy
Authors:
P. Veščičík; I. Kacerovská Musilová; J. Stráník; M. Štěpán; M. Kacerovský
Authors‘ workplace:
Porodnická a gynekologická klinika FN, Hradec Králové, přednosta prof. MUDr. Špaček Jiří, Ph. D., IFEPAG
Published in:
Ceska Gynekol 2020; 85(1): 67-70
Category:
Overview
Objective: To summarize current knowledge regarding Lactobacillus crispatus-dominated vaginal microbiota in pregnancy, as well as an association between the presence of Lactobacillus crispatus-dominated vaginal microbiota and pregnancy complications.
Design: Review.
Setting: Department of Obstetrics and Gynecology, University Hospital Hradec Kralove.
Material and methodology: In this review, the results from literature available about the presence of L. crispatus-dominated microbiota in pregnancy are summarized.
Results: Pregnant women with Lactobacillus crispatus-dominated vaginal microbiota is very common in pregnancy and it is associated with a lower risk of preterm delivery.
Conclusion: Lactobacillus crispatus-dominated vaginal microbiota represents an optimal vaginal microbiota in pregnancy
Keywords:
Bacteria – gravidity – community – microbiom – preterm delivery
Sources
1. Borgdorff, H., Tsivtsivadze, E., Verhelst, R., et al. Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women. ISME J, 2014, 8, p. 1781–1793.
2. Borges, S., Silva, J., Teixeira, P. The role of lactobacilli and probiotics in maintaining vaginal health. Arch Gynecol Obstet, 2014, 289, p. 479–489.
3. Brotman, RM., Shardell, MD., Gajer, P., et al. Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy. Menopause, 2014, 21, p. 450–458.
4. Buchta, V. Vaginal microbiome. Ces Gynekol. 83, p. 371–379.
5. Digiulio, DB., Callahan, BJ., Mcmurdie, PJ., et al. Temporal and spatial variation of the human microbiota during pregnancy. Proc Natl Acad Sci U S A, 2015, 112, p. 11060–11065.
6. Donders, GG., Bosmans, E., Dekeersmaecker, A., et al. Pathogenesis of abnormal vaginal bacterial flora. Am J Obstet Gynecol, 2000, 182, p. 872–878.
7. Chaban, B., Links, MG., Jayaprakash, TP., et al. Characterization of the vaginal microbiota of healthy Canadian women through the menstrual cycle. Microbiome, 2014, 2, p. 23.
8. Chandiramani, M., Bennett, PR., Brown, R., et al. Vaginal microbiome-pregnant host interactions determine a significant proportion of preterm labour. Fetal Matern Med Rev, 25, p. 73–78.
9. Kindinger, LM., Bennett, PR., Lee, YS., et al. The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk. Microbiome, 2017, 5, p. 6.
10. Leccese Terraf, MC., Mendoza, LM., Juarez Tomas, MS., et al. Phenotypic surface properties (aggregation, adhesion and biofilm formation) and presence of related genes in beneficial vaginal lactobacilli. J Appl Microbiol, 2014, 117, p. 1761–1772.
11. Macintyre, DA., Chandiramani, M., Lee, YS., et al. The vaginal microbiome during pregnancy and the postpartum period in a European population. Sci Rep, 2015, 5, p. 8988.
12. Mitchell, C., Balkus, JE., Fredricks, D., et al. Interaction between lactobacilli, bacterial vaginosis-associated bacteria, and HIV Type 1 RNA and DNA Genital shedding in U.S. and Kenyan women. AIDS Res Hum Retroviruses, 2013, 29, p. 13–19.
13. Petricevic, L., Domig, KJ., Nierscher, FJ., et al. Characterisation of the vaginal Lactobacillus microbiota associated with preterm delivery. Sci Rep, 2014, 4, p. 5136.
14. Petrova, MI., Lievens, E., Malik, S., et al. Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. Front Physiol, 2015, 6, p. 81.
15. Ravel, J., Gajer, P., Abdo, Z., et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A, 2011, 108, Suppl. 1, p. 4680–4687.
16. Reid, G., Younes, JA., Van Der Mei, HC., et al. Microbiota restoration: natural and supplemented recovery of human microbial communities. Nat Rev Microbiol, 2011, 9, p. 27–38.
17. Rizzo, A., Losacco, A., Carratelli, CR. Lactobacillus crispatus modulates epithelial cell defense against Candida albicans through Toll-like receptors 2 and 4, interleukin 8 and human beta-defensins 2 and 3. Immunol Lett, 2013, 156, p. 102–109.
18. Rogosa, M., Sharpe, ME. Species differentiation of human vaginal lactobacilli. J Gen Microbiol, 1960, 23, p. 197–201.
19. Romero, R., Hassan, SS., Gajer, P., et al. The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome, 2014, 2, p. 4.
20. Shen, J., Song, N., Williams, CJ., et al. Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis. Sci Rep, 2016, 6, p. 24380.
21. Spear, GT., French, AL., Gilbert, D., et al. Human alpha-amylase present in lower-genital-tract mucosal fluid processes glycogen to support vaginal colonization by Lactobacillus. J Infect Dis, 2014, 210, p. 1019–1028.
22. Thomas, S. Döderlein‘s bacillus: Lactobacillus acidophilus. J Infect Dis, 1928, 43, p. 218–227.
23. Van De Wijgert, JH., Borgdorff, H., Verhelst, R., et al. The vaginal microbiota, what have we learned after a decade of molecular characterization? PLoS One, 2014, 9, p. e105998.
24. Van De Wijgert, JH., Verwijs, MC., Turner, AN., et al. Hormonal contraception decreases bacterial vaginosis but oral contraception may increase candidiasis: implications for HIV transmission. AIDS, 2013, 27, p. 2141–2153.
25. Verstraelen, H., Verhelst, R., Claeys, G., et al. Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora. BMC Microbiol, 2009, 9, p. 116.
26. Wessels, JM., Felker, AM., Dupont, HA., et al. The relationship between sex hormones, the vaginal microbiome and immunity in HIV-1 susceptibility in women. Dis Model Mech, 2018, 11.
27. Witkin, SS., Mendes-Soares, H., Linhares, IM., et al. Influence of vaginal bacteria and D- and L-lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: implications for protection against upper genital tract infections. Mbio, 2013, 4.
28. Zhou, X., Brown, CJ., Abdo, Z., et al. Differences in the composition of vaginal microbial communities found in healthy Caucasian and black women. ISME J, 2007, 1, p. 121–133.
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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
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