Pregnancy in women with congenital bleeding disorder

Czech version

Authors: T. Binder ¹; P. Salaj ²; V. Komrska ³
Authors‘ workplace: Gynekologicko-porodnická klinika FZS UJEP a MN, Ústí nad Labem, přednosta doc. MUDr. T. Binder, CSc. ¹; ÚHKT, Praha, přednosta prof. MUDr. P. Cetkovský, Ph. D., MBA ²; Dětská hemato-onkologická klinika 2. LF UK a FN Motol, Praha, přednosta prof. MUDr. J. Starý, DrSc. ³
Published in: Ceska Gynekol 2016; 81(6): 420-425

Overview

The aim of the study:
To highlight the risks associated with pregnancy at women with von Willebrand´s disease or hemophilia. Introduce the rules of multidisciplinary prenatal and peripartal care to minimalize these risks. The article is accompanied by case report where maladministration led to fatal consequences for the newborn.

Design:
Review and case report.

Seatings:
Department Obstetric and Gynecology UJEP and Masaryk´s Hospital Ústí n/Labem, Institute Haematology and Blood Transfer Prague, Children´s Haemato-onkology Clinic University Hospital Prague Motol.

Coclusions:
The pregnancy in both above-mentioned diseases is risky. The close multidisciplinary collaboration is required.

Keywords:
pregnancy, von Willebrad´s disease, hemophilia

Sources

1. Dunkley, SM., Russell, SJ., Rowell, JA., et al. A consensus statement on the management of pregnancy and delivery in women who are carriers of or have bleeding disorders. Med J Aust, 2009, 19, 191(8), p. 460–463.

2. Huq, FY., Kadir, RA. Management of pregnancy, labour and delivery in women with inherited bleeding disorders. Haemophilia, 201, 17, Suppl. 1, p. 20–30.

3. Chee, YL., Townend, J., Crowther, M., et al. Assessment of von Willebrand disease as a risk factor for primary postpartum haemorrhage. Haemophilia, 2012, 18, p. 593–597.

4. James, AH., Jamison, MG. Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost, 2007, 5(6), p. 1165–1169.

5. Kadir, RA., Lee, CA., Sabin, CA., et al. Pregnancy in women with von Willebrand‘s disease or factor XI deficiency. Br J Obstet Gynaecol, 1998, 105(3), p. 314–321.

6. Kujovich, JL. von Willebrand disease and pregnancy. J Thromb Haemost, 2005, 3(2), p. 246–53. Review.

7. Lee, C., Kessler, C., Makris, M., Gough, S. Hemophylia, 2011, 17(1), p. 1365–2516.