Rupture of focal nodular hyperplasia in the 37th week of pregnanacy – case report
Authors:
M. Velíšková 1; R. Vlk 1; Michael Jiří Halaška 1; G. Minajev 1; T. Krejčí 2; Lukáš Rob 1
Authors‘ workplace:
Gynekologicko-porodnická klinika 2. LF UK a FN Motol, Praha, přednosta prof. MUDr. L. Rob, CSc.
1; Chirurgická klinika 2. LF UK a FN Motol, Praha, přednosta prof. MUDr. J. Hoch, CSc.
2
Published in:
Ceska Gynekol 2016; 81(3): 218-221
Overview
Objective:
We describe a case of spontaneous hepatic rupture associated with undiagnosed focal nodular hyperplasia of a patient in the third trimester of pregnancy. Additionally, we provide a brief review of literature.
Design:
Case report.
Setting:
Department of Obstetrics and Gynaecology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague.
Results:
We report the case of a 29 year old patient with otherwise physiological pregnancy, who was hospitalized with pain in left hypochondrium. The patient experienced painful respiration, increasing in intensity in supine position. The possibility of lung embolism was considered and ruled out. Based on a suspected haemoperitoneum, caesarean section was performed. During the inspection of peritoneal cavity a ruptured tumor on the liver was identified. Histological examination showed focal nodular hyperplasia.
Conclusion:
Focal nodular hyperplasia is a benign liver lesion. Complications involving rupture or bleeding are very rare. 17 cases of hepatic rupture associated with focal nodular hyperplasia were described in published reports with only one case related to pregnancy. Our case emphasizes the importance of a close cooperation between a gynaecologist, radiologist and surgeon.
Keywords:
focal nodular hyperplasia, hepatic rupture, haemoperitoneum in pregnancy
Sources
1. Balabaud, C., Al-Rabih, WR., Chen, PJ., et al. Focal nodular hyperplasia and hepatocellular adenoma around the world viewed through the scope of the immunopathological classification. Inter J Hepatol, 2013 (article ID 268625).
2. Becker, YT., Raiford, DS., Webb, L., et al. Rupture of hepatic focal nodular hyperplasia. Amer Surg, 1995, 61, p. 210–214.
3. Brosens, IA., Fusi, L., Brosens, JJ. Endometriosis is a risk factor for spontaneous hemoperitoneum during pregnancy. Fertil Steril, 2009, 92, p. 1243.
4. Gomi, Y., Takagi, K., Matunaga, S., et al. Pregnancy complicated by focal nodular hyperplasia: a case report of one women over two consecutive courses of pregnancy. Clin Case Reports, 2013, 1, p. 38–41.
5. Hunt, CM., Sharara, AI. Liver disease in pregnancy. Amer Family Physician, 1999, 15, 59, p. 829–836.
6. Chang, SKY., Chung, YFA., Thng, CH., Loo, HW. Focal nodular hyperplasia presenting as acute abdomen. Singapore Med J, 2005, 46, p. 90–92.
7. Chiorean, L., Badea, R., Dudea, S., et al. An atypical case of focal nodular hyperplasia. Problems of imagistic diagnosis. Med Ultrasouns, 2014, 16, 1, p. 70–74.
8. Kim, MJ., Han, SY., Baek YH., et al. A case of focal nodular hyperplasia with growth progression during pregnancy. Clin Molecular Hepatol, 2014, 20, p. 392–397.
9. Kleespies, A., Settmacher, U., Neuhaus, P. Spontanruptur einer fokal nodularen Hyperplasie der Leber – Eine seltene Ursache der akuten intraabdominellen Blutung. Zentralbl Chir, 2002, 127, S. 326–328.
10. Koch, N., Gintzburger, D., Seelentag, W., et al. Rupture d´une hyperplasie nodulaire focale. A propos de deux cas. Ann Chirurg, 2006, p. 279–282.
11. Mathieu, D., Kobeiter, H., Maison, P., et al. Oral contraceptive use and focal nodular hyperplasia of the liver. Gastroenterology, 2000,118, p. 560–564.
12. Nguyen, BN., Fléjou, JF., Terris, B., et al. Focal nodular hyperplasia of the liver: a comprehensive pathologic study of 305 lesions and recognition of new histologic forms. Am J Surg Pathol, 1999, 23, p. 1441.
13. Rahili, A., Cai, J., Trastour, C., et al. Spontaneous rupture and hemorrhage of hepatic focal nodular hyperplasia in lobus caudatus. J Hepato-Biliary-Pancreatic Surg, 2005, 12, p. 138–142.
14. Rifai, K., Mix, H., Krusche, S., et al. No evidence of substantial growth progression or complications of large focal nodular hyperplasia during pregnancy. Scand J Gastroenterol, 2013, 48, 1, p. 88–92.
15. Šimetka, O., Vlk, R., Procházka, M. HELLP syndrom. Praha: Maxdorf 2013, s. 77.
16. Wanless, IR., Mawdsley, C., Adams, R. On the pathogenesis of focal nodular hyperplasia of the liver. Hepatology, 1985, 5, 1194.
17. Weimann, A., Mossinger, M., Fronhoff, K., et al. Pregnancy in women with observed focal nodular hyperplasia of the liver. Lancet, 1998, 35, p. 1251–1252.
18. Yajima, D., Kondo, F., Nakatani, Y., et al. A fatal case of subcapsular liver hemorrhage in late pregnancy: A review of hemorrhages caused by hepatocellular hyperplastic nodules. J Forensic Sci, 2013, 58, p. 253–257.
Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2016 Issue 3
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