Myo-inositol in the treatment of polycystic ovary syndrome

Czech version

Authors: P. Křepelka
Authors‘ workplace: Katedra gynekologie a porodnictví 3. LF UK, Praha ; Katedra gynekologie a porodnictví IPVZ, Praha ; Ústav pro péči o matku a dítě, Praha, přednosta doc. MUDr. J. Feyereisl, CSc.
Published in: Ceska Gynekol 2014; 79(3): 242-246

Overview

Objective:
Presentation of a comprehensive body of knowledge on the role of insulin sensitizer myo-inositol in the treatment of polycystic ovary syndrome (PCOS).

Design:
Review article.

Setting:
Institute for the Care of Mother and Child, Prague.

Method:
An overview of publishing data.

Results and conclusion:
Polycystic ovary syndrome is the most common cause of ovarian dysfunction and anovulatory infertility in women. The insulin resistance occurs very frequently as a part of PCOS. This paper reviews the literature documenting the effectiveness of insulin sensitizer myo-inositol in the treatment of ovarian dysfunction, symptoms of hyperandrogenism and wide complex of symptoms of metabolic syndrome. Six randomized controlled trials provides evidence of a positive effect of myo-inositol to normalize ovarian function, improve laboratory and clinical manifestations of hyperandrogenism and insulin resistance. The myo-inositol treatment has been demonstrated as a safe method of PCOS management.

Keywords:
polycystic ovary syndrome, insulin resistance syndrome, insulin sensitizers, myoinositol, metformin

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