Selective progesterone receptor modulators and their therapeutical use

Czech version

Authors: D. Driák ¹; B. Sehnal ¹; I. Švandová ²
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a Nemocnice Na Bulovce, Praha, přednosta prof. MUDr. M. Halaška, DrSc. ¹; Oddělení neurobiologie, Katedra fyziologie, Přírodovědecká fakulta UK, Praha ²
Published in: Ceska Gynekol 2013; 78(2): 175-181

Overview

Currently developed selective progesterone receptor modulators (SPRMs) are steroid derived compounds with a bulky radical substitution at carbon 11. They interact with progesterone receptor and exert antagonistic or/and agonistic effects. Mifepristone was approved for pregnancy termination and ulipristal acetate as emergency contraception and pharmacological therapy of uterine fibroids. SPRMs inhibit endometrial proliferation and myoma growth, this suggests a therapeutical effect in cases of endometriosis and other estrogen-dependent diseases.

Keywords:
progesterone – progesterone receptor –selective progesterone receptor modulators – agonists and antagonists of progesterone – pregnancy termination – emergency contraception

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