The Impact of PET in Radiotherapy of the Cervical Carcinoma – Results of Pilot Study

Czech version

Authors: H. Doleželová ¹; P. Šlampa ¹; K. Bolčák ²; J. Gombošová ¹; B. Ondrová ¹; T. Novotný ¹; L. Hynková ¹; J. Růžičková ¹; M. Forbelská ³
Authors‘ workplace: Klinika radiační onkologie LF MU a MOÚ, Brno, přednosta prof. MUDr. P. Šlampa, CSc. ¹; Masarykův onkologický ústav, odd. nukleární medicíny, Brno ²; Přírodovědecká fakulta MU, Katedra aplikované matematiky, Brno ³
Published in: Ceska Gynekol 2008; 73(3): 135-140

Overview

Objective:
Positron emission tomography (PET) is a complementary method to determine target volumes in radiotherapy. Daily using of PET in the oncology praxis can change treatment strategy and improve its outcome. Results of this pilot study show the role of PET in staging of cervical carcinoma and in the radiotherapeutic planning.

Methods:
Between March 2005 and May 2007, 51 patients with cervical carcinoma were treated with combination of external beam radiotherapy and HDR brachytherapy, with or without concomitant cisplatin. The lymphatic nodes treatment field size was determined by PET/CT fusion.

Results:
The difference in the results of PET and CT was evaluated in this study. In 32 cases (62.75%) the results of PET and CT were identical, in 14 cases (27.45%) the nodal involvement was more extensive according to PET, in 5 cases (9.8%) the nodal involvement was more extensive according to CT. PET results 3 months after treatment were as follows: in 3 cases (5.88%) stable disease, in 35 cases (68.63%) negative, in 4 cases (7.84%), progression of disease, in 3 cases (5.88%) partial regression.

Conclusion:
The results of this study confirmed the important role of PET in diagnosis and treatment of cervical carcinoma and in determination of target volumes in radiotherapy. PET was found to be a standard staging examination of cervical carcinoma in Masaryk Memorial Cancer Institute.

Key words:
positron emission tomography, radiotherapy, cervical carcinoma.

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