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Bleeding Pattern in Combined Oral Contraceptive(ethinylestradiol 35 g/norgestimate 250 g) Users:Influence of Regularity of Use and Start Day in theFirst Cycle


Authors: V. Paseková 1;  K. Chroust 2
Authors‘ workplace: Repromeda, Centrum reprodukční medicíny, Brno, primář MUDr. J. Veselý 2Katedra genetiky amolekulární biologie, Přírodovědecká fakultaMU, Brno, vedoucí doc. RNDr. J. Doškař, CSc. 1
Published in: Ceska Gynekol 2003; (2): 84-88
Category:

Overview

ective:
To assess the frequency of irregular intermenstrual bleeding in combined oral contraceptive(ethinylestradiol 35 g/norgestimate 250 g, COC) users and the influence of regularity of pilluse on this frequency; to assess the occurrence of withdrawal bleeding during weekends in womenusing the COC from the first Sunday in the cycle (Sunday start method).Design: Prospective, open, non-comparative, multicenter study in 27 centers.Methods: The first day of the pill use, occurrence of intermenstrual and withdrawal bleeding andregularity of use were assessed by means of patient’s bleeding diary. Body weight, blood pressureand side effects were monitored before the oral contraceptive use and after the third cycle.Results: 358 (94%) of 382 women completed the study. Frequency of intermenstrual bleeding wasgenerally low (6.7%, 5.0% and 5.0% in the first, second and third cycle) and highly influenced byregularity of pill use (2.6%, 0% a 1% in regular users versus 30.2 %, 32.1 % a 24,2 % in irregular users).28%, 40% and 47% of Sunday start users achieved bleeding-free weekends after the first, second andthird cycle. Body weight and blood pressure did not change during the study.Conclusion: Frequency of intermenstrual (breakthrough) bleeding during the first three months ofCOC use is highly influenced by regularity of use. In regular users of monophasic COC containingethinylestradiol 35 g/norgestimate 250 g the frequency of intermenstrual bleeding is bellow 2.6%.In Sunday start users the proportion of women with bleeding-free weekends (i.e. weekends withoutthe occurrence of withdrawal bleeding) increases to 47% after the third cycle.

Key words:
oral contraceptives, norgestimate, ethinylestradiol, cycle control, Sunday start

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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology


2003 Issue 2

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