Facial Clefts in 1961–2000: Incidence, PrenatalDiagnosis and Prevalence by Maternal Age

Czech version

Authors: A. Šípek ¹; V. Gregor ²; J. Horáček ²; D. Mašátová ³
Authors‘ workplace: Ústav pro péči o matku a dítě, Praha-Podolí, ředitel doc. MUDr. J. Feyereisl, CSc. 2Oddělení lékařské genetiky, Fakultní Thomayerova nemocnice, Praha, ředitel ing. J. Pubrdle 3Ústav zdravotnických informací a statistiky České republiky, Praha, ředitelka M ¹
Published in: Ceska Gynekol 2002; (5): 260-267
Category:

Overview

Objective:
Presentation of the incidence of cleft lip with or without cleft palate in the CzechRepublic during 1961 to 2000. Design: Retrospective demographic epidemiological study.Setting: Institute for the Care of Mother and Child in Prague (period 1961–1990) were used as wellas data from the nationwide registration of birth defects of infants ensured by the Institute ofHealth Information and Statistics of the Czech Republic covering the period 1987–2000. Epidemiologicalanalysis of the incidence of cleft lip with or without cleft palate diagnosed in the CzechRepublic during 1961–2000. Mathematical statistical analysis of the prevalence of these defectsby maternal age, the method of calculation of the 95% confidence limit of probability was used.Results: From a consecutive series of 5 589 888 births in the CR during 1961–2000 a 1166 cases ofcleft lip, 5052 caes of cleft lip and palate were diagnosed and 3970 cases of cleft palate. A total of 10188 caes of facial clefts were recorded. The mean incidence of cleft lip was during the investigationperiod 2.09 per 10 000 liveborn infants, the incidence of cleft lip with/without cleft palate 11.13per 10 000 liveborn infants. The mean incidence of cleft palate during the investigation periodwas 7.10 per 10 000 liveborn infants and of facial clefts as a whole 18.23 per 10 000 liveborninfants.Conclusion: The authors provided evidence that the frequency of facial clefts as a whole duringthe investigation period did not undergo significant changes as regards the trend of incidence.When evaluating maternal age as one of the risk factors for the development of facial clefts theinvestigation confirmed a greater risk in 15-year-old women and women older than 35 yearswithout exception, in the group aged 29–84 years with the exception of 32.32 and 34 years (liminalfindings).

Key words:
congenital defect, cleft lip with or without cleft palate, cleft palate, incidence, CzechRepublic, maternal age

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