MOLAR INCISOR HYPOMINERALIZATION

Czech version

Authors: M. Hepová; M. Miklasová; T. Kovalský; E. Míšová
Authors‘ workplace: Klinika zubního lékařství, Lékařská fakulta Univerzity Palackého a Fakultní nemocnice, Olomouc
Published in: Česká stomatologie / Praktické zubní lékařství, ročník 122, 2022, 2, s. 43-49
Category: Review Article
doi: https://doi.org/10.51479/cspzl.2022.004

Overview

Introduction, aim: The number of patients with affected enamel in molar incisor hypomineralization is increasing in the dental offices in recent years. It is a hypomineralization of systemic origin affecting at least one first permanent molar, often associated with affected permanent incisors. The etiology of this disease is not fully understood. The literature mentions influences of external environment and contemplates genetic factors. We reconstruct the hard dental tissues loss of permanent molars and improve the aesthetics of incisors in these cases. The therapy is based on the condition of the teeth, cooperation and age of the patient. We must approach each patient individually and choose the appropriate therapy for them. The aim of this article is to summarize the available information on etiopathogenesis, classification, histological changes and clinical picture, prevention and therapy of molar incisor hypomineralization.

Methods: The PubMed and Web of Science databases were used to gather articles for this review. The publications were searched in English language using the key words: MIH, molar, incisor, molar incisor hypomineralization, DDE, hypomineralization, opacity. Articles published between 2006 and 2021 were used as sources for this review.

Conclusions: Early diagnosis and implementation of preventive procedures are important to avoid possible complications related to molar incisor hypomineralization. Moreover, the prevalence of this desease in the population is increasing and patients affected by molar incisor hypomineralization are more frequently encountered in the dental office.

Keywords:

Opacity – MIH – molar – incisor – molar incisor hypomineralization – DDE – hypomineralization

Sources

1. Tourino LF, Corrêa-Faria P, Ferreira RC, Bendo CB, Zarzar PM, Vale MP. Association between molar incisor hypomineralization in schoolchildren and both prenatal and postnatal factors: A populationbased study. PLoS One. 2016; 11(6).

2. Giuca MR, Lardani L, Pasini M, Beretta M, Gallusi G, Campanella V. State-of-the-art on MIH. Part. 1 Definition and aepidemiology. Eur J Paediatr Dent. 2020; 21(1): 80–82.

3. Almuallem Z, Busuttil-Naudi A. Molar incisor hypomineralisation (MIH) – an overview. Br Dent J. 2018; 225: 601–609.

4. Koruyucu M, Özel S, Tuna EB. Prevalence and etiology of molar-incisor hypomineralization (MIH) in the city of Istanbul. J Dent Sci. 2018; 13(4): 318–328.

5. Cabral RN, Nyvad B, Soviero VLVM, Freitas E, Leal SC. Reliability and validity of a new classification of MIH based on severity. Clin Oral Investig. 2020; 24(2): 727–734.

6. Mishra A, Pandey RK. Molar incisor hypomineralization: An epidemiological study with prevalence and etiological factors in Indian pediatric population. Int J Clin Pediatr Dent. 2016; 9(2): 167–71.

7. Lygidakis NA, Wong F, Jälevik B, Vierrou AM, Alaluusua S, Espelid I. Best clinical practice guidance for clinicians dealing with children presenting with molarincisor- hypomineralisation (MIH): An EAPD policy document. Eur Arch Paediatr Dent. 2010; 11(2): 75–81

8. Xie ZH, Mahoney EK, Kilpatrick NM, Swain MV, Hoffman M. On the structure-property relationship of sound and hypomineralized enamel. Acta Biomater. 2007; 3(6): 865–872.

9. Patel A, Aghababaie S, Parekh S. Hypomineralisation or hypoplasia? Br Dent J. 2019; 227(8): 683–686.

10. Marouane O, Douki N. The use of transillumination in detecting subclinical extensions of enamel opacities. J Esthet Restor Dent. 2019; 31(6): 595–600.

11. Zhao D, Dong B, Yu D, Ren Q, Sun Y. The prevalence of molar incisor hypomineralization: evidence from 70 studies. Int J Paediatr Dent. 2018; 28(2): 170–179.

12. Reyes MRT, Fatturi AL, Menezes JVNB, Fraiz FC, Assunção LRDS, Souza JF. Demarcated opacity in primary teeth increases the prevalence of molar incisor hypomineralization. Braz Oral Res. 2019; 33: e048.

13. Elfrink ME, Schuller AA, Weerheijm KL, Veerkamp JS. Hypomineralized second primary molars: prevalence data in Dutch 5-year-olds. Caries Res. 2008; 42(4): 282–285.

14. Elzein R, Chouery E, Abdel-Sater F, Bacho R, Ayoub F. Molar-incisor hypomineralisation in Lebanon: association with prenatal, natal and postnatal factors. Eur Arch Paediatr Dent. 2021; 22(2): 283–290.

15. Krämer N, Bui Khac NN, Lücker S, Stachniss V, Frankenberger R. Bonding strategies for MIH-affected enamel and dentin. Dent Mater. 2018; 34(2): 331–340.

16. Hubbard MJ, Mangum JE, Perez VA, Williams R. A breakthrough in understanding the pathogenesis of molar hypomineralisation: the mineralisation-poisoning model. Front Physiol. 2021; 12: 802833.

17. Lygidakis NA, Garot E, Somani C, Taylor GD, Rouas P, Wong FSL. Best clinical practice guidance for clinicians dealing with children presenting with molarincisor- hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent. 2021. doi: 10.1007/s40368-021-00668-5

18. Kuklik HH, Cruz ITSA, Celli A, Fraiz FC, Assunção LRDS. Molar incisor hypomineralization and celiac disease. Arq Gastroenterol. 2020; 57(2): 167–171.

19. Mathu-Muju K, Wright JT. Diagnosis and treatment of molar incisor hypomineralization. Compend Contin Educ Dent. 2006; 27: 604–610.

20. de Souza JF, Fragelli CB, Jeremias F, Paschoal MAB, Santos-Pinto L, de Cássia Loiola Cordeiro R. Eighteen-month clinical performance of composite resin restorations with two different adhesive systems for molars affected by molar incisor hypomineralization. Clin Oral Investig. 2017; 21(5): 1725–1733.

21. Alifakioti E, Arhakis A, Oikonomidis S, Kotsanos N. Structural and chemical enamel characteristics of hypomineralised second primary molars. Eur Arch Paediatr Dent. 2021; 2(3): 361–366.

22. Jälevik B, Szigyarto-Matei A, Robertson A. The prevalence of developmental defects of enamel, a prospective cohort study of adolescents in Western Sweden: a Barn I TAnadvarden (BITA, children in dental care) study. Eur Arch Paediatr Dent. 2018; 19(3): 187–195.

23. Negre-Barber A, Montiel-Company JM, Boronat-Catalá M, Catalá-Pizarro M, Almerich-Silla JM. Hypomineralized second primary molars as predictor of molar incisor hypomineralization. Sci Rep. 2016; 6: 31929.

24. Kopperud SE, Pedersen CG, Espelid I. Treatment decisions on Molar-Incisor Hypomineralization (MIH) by Norwegian dentists – a questionnaire study. BMC Oral Health. 2016; 17(1): 3.

25. Raposo F, de Carvalho Rodrigues AC, Lia ÉN, Leal SC. Prevalence of hypersensitivity in teeth affected by Molar-Incisor Hypomineralization (MIH). Caries Res. 2019; 53(4): 424–430.

26. Lygidakis NA. Treatment modalities in children with teeth affected by molar-incisor enamel hypomineralisation (MIH): A systematic review. Eur Arch Paediatr Dent. 2010; 11(2): 65–74.

27. Toumba KJ, Twetman S, Splieth C, Parnell C, van Loveren C, Lygidakis NΑ. Guidelines on the use of fluoride for caries prevention in children: an updated EAPD policy document. Eur Arch Paediatr Dent. 2019; 20(6): 507–516.

28. Fragelli CMB, Souza JF, Bussaneli DG, Jeremias F, Santos-Pinto LD, Cordeiro RCL. Survival of sealants in molars affected by molar-incisor hypomineralization: 18-month follow-up. Braz Oral Res. 2017; 31: e30.

29. Davari A, Ataei E, Assarzadeh H. Dentin hypersensitivity: etiology, diagnosis and treatment; a literature review. J Dent (Shiraz). 2013; 14(3): 136–145.

30. Negre-Barber A, Montiel-Company JM, Catalá-Pizarro M, Almerich-Silla JM. Degree of severity of molar incisor hypomineralization and its relation to dental caries. Sci Rep. 2018; 8(1): 1248.

31. Lagarde M, Vennat E, Attal JP, Dursun E. Strategies to optimize bonding of adhesive materials to molar-incisor hypomineralizationaffected enamel: A systematic review. Int J Paediatr Dent. 2020; 30(4): 405–420.

32. Davidovich E, Dagon S, Tamari I, Etinger M, Mijiritsky E. An innovative treatment approach using digital workflow and CAD-CAM Part 2: The restoration of molar incisor hypomineralization in children. Int J Environ Res Public Health. 2020; 17(5): 1499.

33. Ekambaram M, Anthonappa RP, Govindool SR, Yiu CKY. Comparison of deproteinization agents on bonding to developmentally hypomineralized enamel. J Dent. 2017; 67: 94–101.

34. Bandeira Lopes L, Machado V, Botelho J, Haubek D. Molar-incisor hypomineralization: an umbrella review. Acta Odontol Scand. 2021; 79(5): 359–369.

35. Wuollet E, Tseveenjav B, Furuholm J, Waltimo-Sirén J, Valen H, Mulic A, Ansteinsson V, Uhlen MM. Restorative material choices for extensive carious lesions and hypomineralisation defects in children: a questionnaire survey among Finnish dentists. Eur J Paediatr Dent. 2020; 21(1): 29–34.

36. Somani C, Taylor GD, Garot E, Rouas P, Lygidakis NA, Wong FSL. An update incisor hypomineralisation (MIH): a systematic review. Eur Arch Paediatr Dent. 2021. doi: 10.1007/s40368-021-00635-0

37. Žižka R, Šedý J, Voborná I. Retreatment of failed revascularization/ revitalization of immature permanent tooth – a case report. J Clin Exp Dent. 2018; 10(2): e185–e188.

38. Saitoh M, Shintani S. Molar incisor hypomineralization: A review and prevalence in Japan. Jpn Dent Sci Rev. 2021; 57: 71–77.

39. Bhandari R, Thakur S, Singhal P, Chauhan D, Jayam C, Jain T. Concealment effect of resin infiltration on incisor of Grade I molar incisor hypomineralization patients: An in vivo study. J Conserv Dent. 2018; 21(4): 450–454.