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Borna Disease Virus (BDV) and Psychical Disorders


Authors: S. Racková 1;  L. Janů 1;  H. Kabíčková 2
Authors‘ workplace: Psychiatrická klinika LF UK a FN, Plzeň 1;  Klinlab, s. r. o., Ústřední vojenská nemocnice Střešovice, Praha 2
Published in: Čes. a slov. Psychiat., 104, 2008, No. 8, pp. 426-436.
Category: Comprehensive Reports

Overview

Description, characteristics: Borna disease virus (BDV) is a RNA virus which belongs to the family of Bornaviridae, order Mononegavirales. BDV is characterised with a high affinity to the limbic system.

Mechanism of influence:
BDV antigens bind to the neurotransmitter receptors and BDV infection increases the production of cytokines which indirectly influence the neurotransmitter systems too. BDV causes the infection of warm-blooded animals characterised with the damage of the central nervous system (CNS) with mood and behaviour changes.

BDV and psychic disorders:
The higher positivity of BDV infection is detected in patients with psychiatric disorders in comparison with the lower positivity in healthy individuals. We suppose that there is a connection between the course of psychiatric disorders and BDV infection. The virostatic medication-amantadine is used in the treatment of this infection. This treatment is connected with the faster improvement of psychic status of patients.

Key words:
BDV, psychiatric disorders, depression, schizophrenia, amantadine.


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