ADHD – Symptoms and Gender
Authors:
E. Malá
Authors‘ workplace:
Psychiatrická ordinace, Neurologická klinika 1. LF UK, Praha
Published in:
Čes. a slov. Psychiat., 104, 2008, No. 4, pp. 172-179.
Category:
Comprehensive Reports
Overview
Hyperkinetic disorders are classified into category F90 according to the International Classification of Diseases (ICD) and into attention deficit hyperactivity disorders (ADHD) according to the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) and are found in all age groups from childhood to adulthood. From results of the latest research and clinical experiences it follows that for rational and effective therapy the subtypes of ADHD must be distinguished. It is also important that ADHD in boys and girls exhibits gender differences. Neurodevelopmental delay and frequent minimal organic damage with accumulated external stress lead to maladaptive behaviour with high psychiatric comorbidity. Children with ADHD display genetic influences, abnormal maturation of CNS followed with the abnormal development of neurotransmitter systems. The disorder is successfully treated with stimulants, and since 2002 /Czech Rep. 2007/ also with atomoxetine. The disorder is due to interactions with genetic, neurobiologic and environmental /epigenetic/ factors.
Key words:
ADHD, different subtypes, gender differences, comorbidity, therapy - methylphenidate, atomoxetine.
Sources
1. Adler, L. A., Spencer, T, J., Milton, D. R.: Long-term, open label study of the safety and efficacy of atomoxetine in adults with attention-deficit/hyperactivity disorder. An interim analysis. J. Clin.Psychiatry, 66, 2005, 3, pp. 294-299.
2. Adler, L. A., Chua, H. C.: Management of ADHD in adults. J. Clin. Psychiatry, 63 (Suppl 12), 2002, pp. 29-35.
3. Allen, A. J., Kurlan, R. M., Gilbert, D. L. et al.: Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders. Neurology, 65, 2005, pp. 1941-1949.
4. Bangs, M. E., Emslie, G. J., Spencer, T. J. et al.: Atomoxetine ADHD and comorbid MDD study group and metaregression analysis. J.Psychiatry, 164, 2007, pp. 942–948.
5. Balk, E. M., Bonis, P. A., Moskowitz, H. et al.: Correlation of quality measures with estimates of treatment effect in meta-analyses of randomized controlled trials. JAMA, 287, 2002, pp. 2973-2982.
6. Barkley, R.: Attention-deficit hyperactivity disorder. Sci Am., 279, 1998, 3, pp. 66-71.
7. Barkley, R. A., Fischer, M., Smallish, L. et al.: Young adult outcome of hyperactive children. Adaptive functioning in major life activities. J. Am. Acad. Child Adolesc. Psychiatry, 45, 2006, pp. 192-202.
8. Becker, K., Buitelaar, J. K., Danckaerts, M. et al.: Does atomoxetine treatment improve psychosocial and family functioning in children and adolescents with ADHD? Acta Psych. Scand., 2004, pp. 110-148.
9. Biederman, J., Ball, S. W., Monuteaux, M. C. et al.: Are girls with ADHD at risk for eating disorders? Results from a controlled, five-year prospective study. J. Dev. Behav. Pediatr., 284, 2007, pp. 302-307.
10. Bush, G., Valera, E. M., Seidman, L. J.: Functional neuroimaging of attention-deficit/hyperactivity disorder. A review and suggested future directions. Biological Psychiatry, 57, 2005, pp. 1273-1284.
11. Castellanos, F. X., Giedd, J. N., Berquin, P. C. et al.: Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder. Arch. Gen. Psychiatry, 58, 2001, 3, pp. 289-295.
12. Cohen, J.: A power primer. Psychological Bulletin, 112, 1992, pp. 155-159.
13. Cote, S., Zoccolillo, M.,Tremblay, R.et al.: Predicting girls’ conduct disorder in adolescence from childhood trajectories of disruptive behaviors J. Am. Acad. Child Adolesc. Psychiatry, 40, 2001, 6, pp. 678-684.
14. Dalsgaard, S., Mortensen, P. B., Frydenberg, M. et al.: Conduct problems, gender and adult psychiatric outcome of children with attention-deficit hyperactivity disorder. Br. J. Psychiatry, 181, 2002, pp. 416-421.
15. Donnelly, C. L., Matza, L., Rentz, A. et al.: The effect of atomoxetine on the social and family functioning of children and adolescents with attention-deficit/hyperactivity disorder. Poster presentation, 15th Congress of the European College of Neuropsychopharmacology (ECNP), Barcelona, 2002. In: Europ. Neuropsychopharm. 12, 2002, (Suppl 3), p. 437.
16. Drtílková, I., Hrdlička, M., Paclt, I.: Klinická vodítka léčby hyperkinetické poruchy u dětí. Psychiatrie. Doporučené postupy psychiatrické péče II. Infofarm, 2006, pp. 141-146.
17. Drtílková, I., Šerý, O. et al.: Hyperkinetická porucha. Galen, 2007, s. 268.
18. Faraone, S. V.: Etiology and pathophysiology of adult attention-deficit/hyperactivity disorder. Primary Psychiatry, 11, 2004, 7, p. 28-40.
19. Geller, D., Donnelly, C., Lopez, F.: Atomoxetine treatment for pediatric patients with attention-deficit/ hyperactivity disorder with comorbid anxiety disorder. J. Am. Acad. Child Adolesc. Psychiatry, 46, 2007, pp. 1119–1127.
20. Gross, T. V., Goldzweig, G., Landau, Y. E. et al.: The impact of sex and subtypes on cognitive and psychosocial aspects of ADHD. Develop. Med. Child Neurology, 48, 2006, 11, pp. 901-905.
21. Hrdlička. M.: Postaveni atomoxetinu v léčbě hyperkinetické poruchy u dětí a adolescentů. Čes a slov. Psychiat., 103, 2007, 5, s. 230-239.
22. Kratochvil, C. J., Newcorn, J., Gao, H.: Atomoxetine for comorbid ADHD and affective symptoms. Poster presentation, 50th Anniversary Meeting of the American Academy of Child and Adolescent Psychiatry -Miami Beach (USA), 2003. In: Findling R.(Ed.): Scientific Proceedings of the 50th Anniversary Meeting of the J. Am. Acad. Child Adolesc. Psychiatry,. 2003, p. 160.
23. Lahey, B. B., Hartung, C. M., Loney, J. et al.: Are there sex differences in the predictive validity of DSM-IV ADHD among younger children? J. Clin. Child Adolesc. Psychol,. 36, 2007, 2, pp. 113-126.
24. Laupacis, A., Sackett, D. L., Roberts, R. S.: An assessment of clinically useful measures of the consequences of treatment. N. Engl. J. Med., 318, 1988, pp. 1728-1733.
25. Lee, S. S., Hinshaw, S. P.: Predictors of adolescent functioning in girls with attention deficit hyperactivity disorderthe role of childhood ADHD, conduct problems, and peer status. J. Clin .Child Adolesc. Psychol., 35, 2006, 3, pp. 356-368.
26. Lewis, D., Linder, S., Kurlan, R.: Atomoxetine for the treatment of attention deficit hyperactivity disorder and comorbid tics in children. Annals of Neurology, 54, 2003, (Suppl 7), p. 106.
27. Malá, E., Kučera, Z.: :Atomoxetin. Remedia, 17, 2007, s. 542-550.
28. Malá, E.: Hyperkinetické poruchy /ADHD/. ZN-lékařské listy, 20, 2007, s. 6-9.
29. Michelson, D., Adler, L., Spencer, T. et al.: Atomoxetine in adults with ADHD: Two randomized, placebo-controlled studies. Biol. Psychiatry, 53, 2003, 2, pp. 112-120.
30. Michelson, D., Adler. L., Spencer, T. et al.: Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies. Biolog.Psychiatry, 53, 2003a, 2, pp.112-120.
31. Michelson, D., Buitelaar, J. K., Danckaerts, M. et al.: Relapse prevention in pediatric patients with ADHD treated with atomoxetine: a randomized, double-blind, placebo-controlled study. Am. Acad. Child Adolesc. Psychiatry, 43, 2004, pp. 896-904.
32. Newcorn, J. H., Spencer, T. J., Biederman, J. et al.: Atomoxetine treatment in children and adolescents with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder. J. Am. Acad. Child Adolesc. Psychiatry, 44, 2005, pp. 240–248.
33. Novik, T. S., Hervas, A., Ralston, S. J. et al.: Influence of gender on Attention-Deficit/Hyperactivity Disorder in Europe - ADORE. Eur. Child Adolesc. Psychiatry, 15, 2006, ‚Suppl), pp. 115-124.
34. Ohan, J. L., Johnston, C.: What is the social impact of ADHD in girls? A multi-method assessment. J. Abnorm. Child Psychol., 35, 2007, 2, pp. 239-250.
35. Paclt, I. et al.: Hyperkinetická porucha a poruchy chování. Grada, 2007, s. 234.
36. Pajer, K., Gardner, W., Rubin, R. T. et al.: Decreased cortisol levels in adolescent girls with conduct disorder. Arch. Gen. Psychiatry, 58, 2001, 3, pp. 297-302.
37. Pliszka, S. R.: Psychiatric comorbidities in children with attention deficit hyperactivity disorder. Implications for management. Pediatric Drugs, 5, 2003, pp. 741-750.
38. Polanczyk, G., Silva de Lima, M., Horta, B. L. et al.: The worldwide prevalence of ADHD: A systematic review and metaregression analysis. Am. J. Psychiat., 164, 2007, 6, p. 856.
39. Simpson, D., Plosker, G. L.: Atomoxetine: a review of its use in adults with attention deficit hyperactivity disorder. Druha, 64, 2004, pp. 205–222.
40. Sonuga Barke, E. J., Coghill, D., Markowitz, J. S. et al.: Sex differences in the response of children with ADHD to once-daily formulations of methylphenidate. Am. Acad. Child Adolesc. Psychiatry,. 46, 2007, 6, pp. 701-710.
41. :Spenser, T. J., Sallee, R., Gilbert, D. L. et al: Atomoxetine Treatment of ADHD in children with comorbid Tourette Syndrome. J. Atten. Disord,. 12, 2007 [Epub ahead of print].
42. Staller, J., Faraone, S. V.: Attention-deficit hyperactivity disorder in girls: epidemiology and management CNS-Drugs, 20, 2006, 2, pp. 107-123.
43. Valdizan, J. R., Mercado, E., Mercado-Undanivia, A.: Clinical variability and characteristics of attention deficit hyperactivity disorder in girls. Rev. Neurol., 44 (Suppl 2), 2007, 2, pp. 27-30.
44. Vohlídka, P.: Observační studie vs. randomizované kontrolované studie? Psychiat. pro praxi, 9, 2008, s. 4-9.
45. Wender, P. H.: Attention-deficit hyperactivity disorder in adults. Oxford.University Press, 1995.
46. Wernicke, J. F., Adler, L., Spencer, T. et al.: Changes in symptoms and adverse events after discontinuation of atomoxetine in children and adults with attention deficit/ hyperactivity disorder: a prospective, placebo-controlled assessment. J. Clin. Psychopharmacology, 24, 2004, 1, pp. 1-6.
47. Willcutt, E. G., Doyle, A. E., Nigg, J. E. et al.: Validity of the executive function theory of attention-deficit/hyperactivity disorder. A meta-analytic review. Biological Psychiatry, 57, 2005, pp. 1336-1346.
Labels
Addictology Paediatric psychiatry PsychiatryArticle was published in
Czech and Slovak Psychiatry
2008 Issue 4
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