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Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone


Authors: Lucie Černá 1,2;  Zuzana Ba O 1;  Petra Šalamúnová 4;  Karel Šmejkal 1,3;  Jaroslav Hanuš 4;  Jan Hošek 2
Authors‘ workplace: Farmaceutická fakulta, Masarykova univerzita, Brno 1;  Přírodovědecká fakulta, Univerzita Palackého, Oddělení biologicky aktivních komplexů a molekulových magnetů, Regionální centrum pokročilých technologií a materiálů 2;  Univerzita veterinárskeho lekárstva a farmácie, Katedra farmakognózie a botaniky, Košice, SR 3;  Vysoká škola chemicko-technologická, Praha, Ústav chemického inženýrství, Fakulta chemicko-inženýrsk 4
Published in: Čes. slov. Farm., 2020; 69, 130-136
Category: Original Articles

Overview

Geranylated flavanone diplacone is a flavanone iso- lated from Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water. Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs). GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of β-(1→3)/β-(1→6) glucan mainly. The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone. The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction. The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor κB (NF-κB) and activator protein 1 (AP-1).

Keywords:

AP-1 – diplacone – encapsulation – glucan particles – NF-κB – inflammation


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