Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone
Authors:
Lucie Černá 1,2; Zuzana Ba O 1; Petra Šalamúnová 4; Karel Šmejkal 1,3; Jaroslav Hanuš 4; Jan Hošek 2
Authors‘ workplace:
Farmaceutická fakulta, Masarykova univerzita, Brno
1; Přírodovědecká fakulta, Univerzita Palackého, Oddělení biologicky aktivních komplexů a molekulových magnetů, Regionální centrum pokročilých technologií a materiálů
2; Univerzita veterinárskeho lekárstva a farmácie, Katedra farmakognózie a botaniky, Košice, SR
3; Vysoká škola chemicko-technologická, Praha, Ústav chemického inženýrství, Fakulta chemicko-inženýrsk
4
Published in:
Čes. slov. Farm., 2020; 69, 130-136
Category:
Original Articles
Overview
Geranylated flavanone diplacone is a flavanone iso- lated from Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water. Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs). GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of β-(1→3)/β-(1→6) glucan mainly. The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone. The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction. The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor κB (NF-κB) and activator protein 1 (AP-1).
Keywords:
AP-1 – diplacone – encapsulation – glucan particles – NF-κB – inflammation
Sources
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Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2020 Issue 3
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