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Vliv formulačních a procesních parametrů na vlastnosti Cu2+/alginátových částic připravených vnější iontovou gelací hodnocený analýzou hlavních komponent Miroslava Pavelková


: Miroslava Pavelková;  Jakub Vysloužil;  Kateřina Kubová;  Sylvie Pavloková;  Eliška Mašková;  David Vetchý
: Čes. slov. Farm., 2019; 68, 69-77
: Original Article

V současné době je metoda vnější iontové gelace v přípravě alginátových částic s úspěchem používána nejen na poli farmacie a medicíny, ale zejména v oblasti biotechnologie. Proto byla příprava alginátových částic a jejich následné hodnocení pomocí analýzy hlavních komponent stěžejním cílem našeho experimentu. Kvůli optimalizaci této metody jsme se zaměřili na hodnocení vlivu různých formulačních (koncentrace polymeru, koncentrace tvrdícího roztoku) a procesních parametrů (velikost vnějšího průměru injekční jehly) na vlastnosti vzniklých částic (výtěžek, sféricita, ekvivalentní průměr a bobtnavost při pH 6). Metodou analýzy hlavních komponent byl zásadní vliv na výsledné vlastnosti alginátových částic potvrzen pouze u koncentrace natrium-alginátu. Tyto výsledky potvrdily spolehlivý a bezpečný potenciál vnější iontové gelace v přípravě částicové lékové formy na bázi alginátu.

Klíčová slova:

hydrogelové částice – vnější iontová gelace – natrium-alginát – měďnaté ionty – hodnocení částicové lékové formy – analýza hlavních komponent


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