Cellular and molecular mechanisms of action of bitter compounds: recent knowledge and perspective
Authors:
Milan Nagy; Pavel Mučaji
Authors‘ workplace:
Katedra farmakognózie a botaniky, Farmaceutická fakulta Univerzity Komenského v Bratislave
Published in:
Čes. slov. Farm., 2016; 65, 132-138
Category:
Review Articles
*Venované Dr.h.c. prof. RNDr. Václavovi Suchému, DrSc. pri príležitosti jeho životného jubilea.
Overview
This overview paper describes in its introductory part bitter-tasting herbal drugs in the context of their traditional use in the loss of appetite and digestive disorders. Then, it mentions current knowledge on signals origin in bitter taste receptors leading to different, unexpected physiological processes. Newly observed biological effects of bitter tastants are correlated with modern trends of their complex study with an aim to develop new drugs primarily acting on bitter taste receptors.
Key words:
T2R • bitter taste receptors • GPCR • bitters • glucose homeostasis • asthma • ghrelin • GLP-1 • solitary chemosensory cells
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Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2016 Issue 4
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