Cationic Eudragit^® Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method

English version

Authors: Jakub Vysloužil; Jana Bavoľárová; Martina Kejdušová; David Vetchý; Kateřina Dvořáčková
Authors‘ workplace: University of Veterinary and Pharmaceutical Sciences Brno ; Department of Pharmaceutics, Faculty of Pharmacy
Published in: Čes. slov. Farm., 2013; 62, 249-254
Category: Original Articles

Overview

Jako potencionální polymery pro přípravu mikročástic metodou odpaření rozpouštědla se hodnotily tři kationtové akrylátové deriváty Eudragit^® RL, Eudragit^® RS a Eudragit^® E 100. Prakticky nerozpustné léčivo mirtazapin a snadno rozpustné léčivo tramadol-hydrochlorid byly vybrány pro enkapsulaci jako modelová léčiva s extrémně rozdílnou rozpustností. Připravené mikrosféry byly podrobeny optické mikroskopii, analýze obsahu léčiva a disoluční zkoušce. Při použití Eudragitu^® RL se nepodařilo vytvořit jakostní mikročástice, zatímco z Eudragitu^® RS a Eudragitu^® E 100 byly připraveny mikročástice optimálního tvaru. Vzorky s enkapsulovaným mirtazapinem vykazovaly prodloužené uvolňování léčiva, disoluční profily vzorků s obsahem tramadolu se blížily okamžitému uvolňování léčiva. Eudragit^® RS poskytoval mikročástice s vyšší enkapsulační účinností, vyšším procentuálním obsahem léčiva v lékové formě a střední velikostí částic byla menší.

Klíčová slova:
mikročástice, odpaření rozpouštědla, prodloužené uvolňování léčiva, Eudragit^®

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