Fyziologické faktory ovlivňující osud léčiva v gastrointestinálním traktu
:
Aleš Franc; Kateřina Dvořáčková; Martina Kejdušová; Roman Goněc
:
Veterinary and Pharmaceutical University Brno
; Department of Pharmaceutics, Faculty of Pharmacy
:
Čes. slov. Farm., 2013; 62, 243-248
:
Review Articles
Lék při perorálním podání prochází gastrointestinálním traktem (GIT), který ovlivňuje jeho další osud v organismu. Jde-li o systémové podání, léčivo se zde uvolňuje z lékové formy, rozpouští se a nakonec vstřebává, případně se jeho zbytky vylučují stolicí. Hlavními faktory, které ovlivňují podaný lék, jsou zejména hodnota pH, doba pasáže, solubilizační schopnost nebo oxido-redukční potenciál v jednotlivých částech GIT. Tyto faktory souvisejí přímo s uvolňováním, vstřebáváním eventuálně stabilitou léčiva a lze je využít v prostředí in vitro k simulaci prostředí GIT a k celkovému designu lékové formy in vivo. Jelikož některé literární údaje nebývají uvedeny v souvislostech a navíc se často liší, tato práce shromažďuje základní hodnoty výše zmiňovaných fyziologických parametrů ve formě přehledového článku.
Klíčová slova:
lék, trávení, vstřebávání, pH, GIT, motilita, trávící enzymy
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Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2013 Issue 6
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