The influence of PVA on the size of oligoester nanoparticles prepared by the emulsion solvent distribution method
Authors:
Eva Valentová; Eva Šnejdrová; Milan Dittrich
Authors‘ workplace:
Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologie
Published in:
Čes. slov. Farm., 2011; 60, 193-199
Category:
Original Articles
Overview
Nanoparticles of poly(DL-lactic acid) (PDLLA) were prepared by the emulsion solvent distribution method. The external aqueous phase was composed of 1.5 and 3.0% solutions of three kinds of low molecular weight polyvinylalcohol (PVA) varying in molecular weight and saponification degree. The internal oil phase was made from a 1% solution of PDLLA dissolved in dichloromethane, chloroform and a mixture of these two solvents. Viscosity and surface tension of these phases were not significantly influenced by the selected solvent or solute quality. Contrary to these results, very different values of nanoparticle size were measured by the PCS method and the values of the zeta potential quantified by a laser Doppler velocimeter. ANOVA method revealed PDLLA solvent quality and PVA type as a significant factors for particle size, while PVA type and its concentration were factors relevant for zeta potential changes. The formation of nanoparticles was not controlled by the mechanism of the pure emulsification process characterised by the Weber number. To a great extent, this process was influenced by solidification and mutual mixing of phases. PVA content variables in nanoparticles were indicative of the hypothesis of a small influence of coalescence on nanoparticles formation.
Key words:
PDLLA nanoparticles – emulsion method of evaporation and separation of solvent – size and potential of nanoparticles
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Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2011 Issue 4
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