Pelletization of melts and liquids
Authors:
Miloslava Rabišková
Authors‘ workplace:
Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků
Published in:
Čes. slov. Farm., 2011; 60, 54-60
Category:
Review Articles
Overview
During the second half of the last century, pelletization methods based on wetting were developed, e.g. agglomeration in coating pans, pelletization plates or fluid-bed equipment, layering of the drug in solution or suspension on inactive spherical cores, extrusion/spheronization and later on also rotoagglomeration in rotogranulators or rotoprocessors. These technologies have become a requisite part of industrial production of solid dosage forms. At present, numerous experimental papers deal with pellet preparation from melts and liquids. These new pelletization methods are the topic of the present article. Pellet preparation from melts is represented by three methods, i.e. fluid hot melt agglomeration, hot melt extrusion, and freeze pelletization. Jet cutting and cryopelletization are the techniques dealing with pellet preparation from liquids.
Key words:
fluid hot melt agglomeration – hot melt extrusion – freeze pelletization – jet cutting – cryopelletization
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Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2011 Issue 2
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