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Isotachophoretic Determination of Desloratadine in Tablets and Syrup


Authors: P. Kubačák;  P. Mikuš;  I. Valášková;  Emil Havránek
Authors‘ workplace: Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmaceutickej analýzy a nukleárnej farmácie
Published in: Čes. slov. Farm., 2005; 54, 266-269
Category: Original Articles

Overview

Desloratadine was determined in two dosage forms (tablets and syrup) with the use of the method of capillary isotachophoresis. Several electrolyte systems of varying composition and varying pH were tested. Two electrolyte systems were selected for the validation of the method and determination of desloratadine in real samples. In both electrolyte systems, the precision, correctness, linearity, robustness, and selectivity of the ITP method were evaluated. The pre-treatment of the sample prior to analysis consisted in dissolving and diluting the pertinent desloratadine-containing dosage form with demineralized water to the required concentration. This pre-treated sample was fed directly to the apparatus.

Key words:
capillary isotachophoresis – desloratadine – tablets – syrup - validation


Labels
Pharmacy Clinical pharmacology
Topics Journals
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