Analytical Profile of 1-(4-Fluorophenyl)-4-[3-(3-propoxyphenylcarbamoyloxy)-2-hydroxypropyl]piperazinium chloride (6f)

Czech version

Authors: E. Sedlárová; I. Malík; J. Csöllei ¹; F. Andriamanty
Authors‘ workplace: Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmaceutickej chémie ; Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav chemických léčiv ¹
Published in: Čes. slov. Farm., 2005; 54, 270-274
Category: Original Articles

Overview

The paper presents the results of an analytical evaluation and a study of some physicochemical properties of a potential antiarrhythmic agent marked as 6f. The melting point, spectral properties, solubility and chromatographic behaviour of the drug on the thin layer were investigated. For the content determination, spectrophotometry in the ultraviolet region of the spectrum at the wavelength of the second absorption maximum of the substance and high-performance liquid chromatography were used.

Key words:
aminopropanoles – antiarrhythmics – Ca²⁺-antagonists – analytical profile

Labels

Pharmacy Clinical pharmacology

Contemporary Programme of Pharmaceutical Studies in Germany

Logistics in the Pharmaceutical Service

Interconversion of Stereochemically Unstable Chiral Drugs: Utilization of Chromatographic Techniques for the Study of Enantiomerization, Calculation of Thermodynamic Parameters Part I: Theoretical Aspects

Composite Tincture from the Tops of the Purple Coneflower (Echinacea purpurea) and the Fruits of the Dog Rose (Rosa canina): Technology of Production and Evaluation of Quality

Isotachophoretic Determination of Desloratadine in Tablets and Syrup

Pharmaceutical Literature in the Library of the Kuks Hospice I. A Contribution to the History of the Hospital Pharmacy of the Brethern of Mercy Called „The Pomergranate“ at Kuks

Article was published in

Czech and Slovak Pharmacy

2005 Issue 6