Enantiomeric Separations of Drugs on the Basis of Macrocyclic Antibiotics

Czech version

Authors: T. Rojkovičová; J. Lehotay; J. Čižmárik
Authors‘ workplace: Katedra analytickej chémie Chemickotechnologickej fakulty Slovenskej technickej univerzity, Bratislava, Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in: Čes. slov. Farm., 2001; , 166-172
Category:

Overview

The present review paper describes the properties of the macrocyclic antibiotics vancomycin,teikoplanin, and ristocetin A, which can be used as stationary phases for separation of theenantiomers of drugs containing a stereogenic centre. It analyzes the results obtained in theseparation of amino acids, its derivatives, loxiglumide, clenbuterol, practolol, carnitine, levodopa,methyldopa, ceftazidine, alkoxyphenylcarbamic acid derivatives, dichloroprop, ketoprofen, warfarin, and ergot alkaloids by means of high-performance liquid chromatography (HPLC)

Key words:
vancomycin - teikoplanin - ristocetin A - stationary phases - properties -separation of enantiomers - HPLC

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Article was published in

Czech and Slovak Pharmacy

2001 Issue 4