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Density of Lyophilised Ophthalmic Lamellae2. Use of the Correlogram of Xerogel Density


Authors: Z. Zatloukal
Authors‘ workplace: Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
Published in: Čes. slov. Farm., 1999; , 72-74
Category:

Overview

The paper examines the vacillation of the density of the foil lyophilised from hydrogel containing40 g/l of hydroxypropylmethylcellulose (HPMC 4000). Lamellae of a diameter of 0.55 cm were formedto estimate the density of cm 2 of xerogel. In comparison with traditional regressive methods, theuse of a two-dimensional correlogram is recommended. The most important finding is the achieve-ment of random vacillation of density in a distance of ca 2 cm in connection with stamping lamellaefrom the lyophilised foil. The findings make it possible to optimise the procedure of pouring hydrogelfor lyophilisation with a subsequent decrease in density vacillation of lyophilised ophthalmiclamellae.

Key words:
lyophilisation – hydroxypropylmethylcellulose – xerogel – density – correlogram

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Labels
Pharmacy Clinical pharmacology

Article was published in

Czech and Slovak Pharmacy


1999 Issue 2

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