Kaposi’s Sarcoma. A Case Report
Authors:
Ondřej Polách 1; Adam Kopecký 1,2; Zdeňka Wandrolová 3; Vladimír Židlík 4; Jan Němčanský 1,2
Authors‘ workplace:
Oční klinika, Fakultní nemocnice Ostrava
1; Katedra kraniofaciálních oborů, LF Ostravské univerzity
2; Oční oddělení, Slezská nemocnice v Opavě
3; Ústav klinické a molekulární patologie a lékařské genetiky, Fakultní nemocnice Ostrava
4
Published in:
Čes. a slov. Oftal., 80, 2024, No. 2, p. 114-118
Category:
Case Report
doi:
https://doi.org/10.31348/2024/16
Overview
Aim: The aim of this case report is to present the case of a patient with iatrogenic Kaposi’s sarcoma afflicting several organs, ocular manifestation.
Case report: In a 74-year-old kidney transplant patient receiving immunosuppressive therapy, iatrogenic Kaposi’s sarcoma (KS) developed in both lower eyelids. Subsequently, KS was confirmed in the region of the left forearm, with suspicion of lesions in the lungs. The ocular tumor was surgically removed with negative margins, requiring no further therapy. The lesion on the left forearm was completely excised. The patient underwent radiotherapy for the lung lesions, and immunosuppressive therapy was reduced.
Conclusion: The case highlights the importance of early identification of KS, its histological verification, radical resection, and multidisciplinary collaboration. Knowledge of the epidemiology of this condition is a key factor in determining the correct diagnosis.
Keywords:
immunosuppression – Kaposi’s sarcoma – radical resection – multidisciplinary collaboration
Sources
- Salmon JF. Kanski’s Clinical Ophthalmology, 9th edition. Londýn: Elsevier 2020;941. ISBN: 978-0-7020-7711-1.
- Iftode N, Rădulescu MA, Aramă ȘS, Aramă V. Update on Kaposi sarcoma-associated herpesvirus (KSHV or HHV8) - review. Rom J Intern Med. 2020 Dec 17;58(4):199-208. doi: 10.2478/rjim-2020-0017
- Mariggiò G, Koch S, Schulz TF. Kaposi sarcoma herpesvirus pathogenesis. Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732):20160275. doi: 10.1098/rstb.2016.0275
- Schneider JW, Dittmer DP. Diagnosis and Treatment of Kaposi Sarcoma. Am J Clin Dermatol. 2017 Aug;18(4):529-539. doi: 10.1007/s40257-017-0270-4
- Radu O, Pantanowitz L. Kaposi sarcoma. Arch Pathol Lab Med. 2013 Feb;137(2):289-94. doi: 10.5858/arpa.2012-0101-RS
- Heissigerová J. a kol. Oftalmologie. 2. vyd. Praha: Maxdorf; 2021. 395.
- Kuchynka P. Oční lékařství. Praha: Grada; 2007. 768.
- Cesarman E, Damania B, Krown SE, Martin J, Bower M, Whitby D. Kaposi sarcoma. Nat Rev Dis Primers. 2019 Jan 31;5(1):9. doi: 10.1038/s41572-019-0060-9
- Rapuano Christopher J. Cornea, third edition, Philadelphia: Wolters Kluwer; 2019. 421.
- Kopecky A, Rokohl AC, Heindl LM. Rekonstruktionstechniken der posterioren Augenlidlamelle [Techniques for the Reconstruction of the Posterior Eyelid Lamella]. Klin Monbl Augenheilkd. 2018 Dec;235(12):1415-1428. German. Epub 2018 Nov 23. doi: 10.1055/a-0751-1069
- Sharma S, Malgotra V, Wani M. Kaposi Sarcoma in an Immunocompetent Patient Treated With Paclitaxel. Cureus. 2023 Jan 11;15(1):e33641. doi: 10.7759/cureus.33641
- Sternbach G, Varon J. Moritz Kaposi: idiopathic pigmented sarcoma of the skin. J Emerg Med. 1995 Sep-Oct;13(5):671-674. doi: 10.1016/0736-4679(95)00077-n
- Dedicoat M, Newton R, Alkharsah KR et al. Mother-to-child transmission of human herpesvirus-8 in South Africa. J Infect Dis. 2004 Sep 15;190(6):1068-1075. Epub 2004 Aug 11. doi: 10.1086/423326
- Sunil M, Reid E, Lechowicz MJ. Update on HHV-8-Associated Malignancies. Curr Infect Dis Rep. 2010 Mar;12(2):147-54. Epub 2010 Mar 26. doi: 10.1007/s11908-010-0092-5
- Dollard SC, Douglas D, Basavaraju SV, Schmid DS, Kuehnert M, Aqel B. Donor-derived Kaposi‘s sarcoma in a liver-kidney transplant recipient. Am J Transplant. 2018 Feb;18(2):510-513. Epub 2017 Oct 25. doi: 10.1111/ajt.14516
- Yarchoan R, Uldrick TS. HIV-Associated Cancers and Related Diseases. N Engl J Med. 2018 Mar 15;378(11):1029-1041. doi: 10.1056/NEJMra1615896
- Grabar S, Costagliola D. Epidemiology of Kaposi‘s Sarcoma. Cancers (Basel). 2021 Nov 14;13(22):5692. doi: 10.3390/cancers13225692
- Goedert JJ, Vitale F, Lauria C et al. Classical Kaposi‘s Sarcoma Working Group. Risk factors for classical Kaposi‘s sarcoma. J Natl Cancer Inst. 2002 Nov 20;94(22):1712-8. doi: 10.1093/jnci/94.22.1712
- Ma JY, Liu JW. Disseminated Kaposi Sarcoma. Clin Cosmet Investig Dermatol. 2022 Aug 20; 15:1711-1714. doi: 10.2147/CCID.S376060
- Tang ASO, Teh YC, Chea CY, Yeo ST, Chua HH. Disseminated AIDS-related Kaposi‘s sarcoma. Oxf Med Case Reports. 2018 Nov 26;2018(12): omy107. doi: 10.1093/omcr/omy107
- Cabral RF, Marchiori E, Takayasu TC, Cabral FC, Batista RR, Zanetti G. Pulmonary Kaposi sarcoma in a human immunodeficiency virus - infected woman: a case report. Cases J. 2009 Jan 2;2(1):5. doi: 10.1186/1757-1626-2-5
- Chaisuparat R, Hu J, Jham BC, Knight ZA, Shokat KM, Montaner S. Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi‘s sarcoma. Cancer Res. 2008 Oct 15;68(20):8361-8. doi: 10.1158/0008-5472.CAN-08-0878
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OphthalmologyArticle was published in
Czech and Slovak Ophthalmology
2024 Issue 2
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