The dentate gyrus – anatomy, vascular supply, function and neuropathology

Czech version

Authors: D. Ospalík ¹; R. Bartoš ^2,3; H. Zítek ²; M. Sameš ²; V. Němcová ³
Authors‘ workplace: Neurologické oddělení, Masarykova, nemocnice, KZ a. s., Ústí nad Labem ¹; Neurochirurgická klinika Univerzity, J. E. Purkyně, Masarykova nemocnice, KZ a. s., Ústí nad Labem ²; Anatomický ústav 1. LF UK, Praha ³
Published in: Cesk Slov Neurol N 2022; 85(5): 405-409
Category: Short Communication
doi: https://doi.org/10.48095/cccsnn2022405

Overview

In short communication, we describe the anatomy of the dentate gyrus including its vascular supply. The dentate gyrus is a small gyrus of the human brain, hidden to the observer (anatomist, neurosurgeon) in the depth of the hippocampal complex. It is ejected to the ambient cistern only by its delicate teethed part. The dentate gyrus is important due to its involvement in the Andersen circuit during the creation and consolidation of the memory track. The anatomical dissection helps us to understand its position to the hippocampus proprius, what clarifies their functional connection (perforant path). This dissection is also important for the neurosurgeon, who performs amygdalohippocampectomy or resection of the mediotemporal glioma. We also deal with nosologic entities united to this complex and striking anatomical area.

Keywords:

memory – Dentate gyrus – Limbic system – neurodegenerative disease – hippocampal formation

Sources

1. Eriksson P, Perfilieva E, Björk-Eriksson T et al. Neurogenesis in the adult human hippocampus. Nat Med 1998; 4 (11): 1313–1317. doi: 10.1038/3305.

2. Grim M, Druga R. Základy anatomie 4a. Centrální nervový systém. Praha: Galén 2020.

3. Amaral DG, Scharfman HE, Lavenex P. The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies). Prog Brain Res 2007; 163: 3–22. doi: 10.1016/S0079-6123 (07) 63001-5.

4. Mégevand P, Groppe DM, Bickel S et al. The hippocampus and amygdala are integrators of neocortical influence: a corticocortical evoked potential study. Brain Connect 2017; 7 (10): 648–660. doi: 10.1089/brain. 2017.0527.

5. Phillips ML, Drevets WC, Rauch SL et al. Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol Psychiatry 2003; 54 (5): 504–514. doi: 10.1016/s0006-3223 (03) 00168-9.

6. Marinković S, De Divitiis O, Nikodijević I. Arteries of the brain and spinal cord: anatomic features and clinical significance. Avellino: De Angelis 1997.

7. Peter J, Lisman J. Structure, function, and plasticity of hippocampal dentate gyrus microcircuits. Front Neural Circuits 2014; 8: 107. doi: 10.3389/fncir.2014.00107.

8. Rusina R, Matěj R. Neurodegenerativní onemocnění. Praha: Mladá fronta 2019: 136–137.

9. Kevin R, Steullet P, Pachoud M et al. Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease. Nat Neurosci 2020; 23 (12): 1567–1579. doi: 10.1038/s41593-020-00728-x.

10. Nelson PT, Dickson DW, Trojanowski JQ et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain 2019; 142 (6): 1503–1527. doi: 10.1093/brain/awz099.

11. Bocchetta M, Iglesias JE, Russell LL et al. Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA. Alzheimers Res Ther 2019; 11 (1): 41. doi: 10.1186/s13195-019-0489-9.

12. Hodges JR, Mitchell J, Dawson K et al. Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases. Brain 2010; 133 (1): 300–306. doi: 10.1093/brain/awp248.

13. Scharfman HE. The dentate gyrus and temporal lobe epilepsy: an „exciting“ era. Epilepsy Curr 2019; 19 (4): 249–255. doi: 10.1177/1535759719855952.

14. Nuninga JO, Mandl RCW, Boks MP et al. Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T. Mol Psychiatry 2020; 25 (7): 1559–1568. doi: 10.1038/s41380-019-03 92-6.

15. Soichiro N, Turner JA, Calhoun VD et al. Dentate gyrus volume deficit in schizophrenia. Psychol Med 2020; 50 (8): 1267–1277. doi: 10.1017/S0033291719001144.