New-onset refractory status epilepticus and considered spectrum disorders (NORSE/ FIRES)

Czech version

Authors: K. Česká; O. Horák; H. Ošlejšková; Š. Aulická
Authors‘ workplace: Klinika dětské neurologie LF MU a FN Brno, Centrum vysoce specializované péče pro farmakorezistentní epilepsie MZ ČR, Brno
Published in: Cesk Slov Neurol N 2018; 81(6): 658-662
Category: Review Article
doi: https://doi.org/10.14735/amcsnn2018658

Overview

New-onset refractory status epilepticus (NORSE) is defined as status epilepticus in a patient without active epilepsy or other preexisting relevant neurological disorder. It is characterized by refractory epileptic seizures, without a clear active structural, toxic, or metabolic cause. In most cases, the disease is preceded by mild febrile illness. Very frequently, the ethiology of NORSE can not be proven (cryptogenic NORSE). In a minority of cases is causal autoimmune encephalitis and viral infection of CNS. Conventional antiepileptic medications show very limited success. Therapy includes immunotherapy, ketogenic diet or another non pharmacological options. The long-term prognosis of patients is variable, in most cases cognitive impairments and epilepsy are present.

Key words:

new-onset refractory status epilepticus – clinical presentation – diagnostic protocol – therapy

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

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