Fingolimod zmírňuje harmalinem navozenou poruchu paměti spojenou s pasivním vyhýbáním a motorické poruchy u potkaního modelu esenciálního tremoru
Authors:
N. Dahmardeh 1,2; M. Asadi-Shekaari 1,2; S. Arjmand 2; M. Haghani 3; M. Shabani 2
Authors‘ workplace:
Department of Anatomical Sciences, Afzalipour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran
1; Intracellular Recording Lab, Kerman Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran
2; Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran
3
Published in:
Cesk Slov Neurol N 2018; 81(6): 691-699
Category:
Original Paper
doi:
https://doi.org/10.14735/amcsnn2018691
Overview
Předklinické údaje naznačují, že fingolimod (FTY), modulátor sfingosin-1-fosfátového receptoru, by mohl být prospěšný pro léčbu běžných neurologických poruch, včetně Parkinsonovy nemoci, RS a epilepsie. V aktuální studii byly studovány účinky FTY na harmalinem navozené motorické a kognitivní poruchy u samců potkanů kmene Wistar. Byly hodnoceny paměť spojená s pasivním vyhýbáním, průzkumné chování, chování související s úzkostí, tremor a motorické funkce. Poruchy paměti pozorované u potkanů, kterým byl podáván harmalin, byly podáním FTY do jisté míry zvráceny. Výsledky ukázaly, že FTY byl schopen obnovit šířku kroku, délku levého a pravého kroku, avšak neobnovil dobu trvání mobility. FTY zlepšil dobu strávenou v závěsu na lanku (wire grip) a na rotující tyči (rotarod). Výsledky naší studie objasnily prospěšné účinky FTY na kognici a motorické funkce u modelu esenciálního tremoru (ET) a naznačují, že modulátory sfingosin-1-fosfátového receptoru mají potenciální neuroprotektivní profil pro léčbu ET.
Klíčová slova:
esenciální tremor – fingolimod – paměť – motorické funkce
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Paediatric neurology Neurosurgery NeurologyArticle was published in
Czech and Slovak Neurology and Neurosurgery
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