Aminoguanidin podávaný subchronicky intrahipokampálně zlepšuje u diabetických potkanů plnění úkolů pasivního vyhýbání a expresi genů z rodiny Bcl-2
Authors:
M. Alipour 1; A. Aminabadi 1; M. Arab-Firouzjaei 2; B. Amini 1; M. R. Jafari 1
Authors‘ workplace:
Department of Physiology and Pharmacology, School of Medicine, Zanjān University of Medical Sciences, Zanjān, Iran
1; Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2
Published in:
Cesk Slov Neurol N 2017; 80/113(5): 584-590
Category:
Original Paper
doi:
https://doi.org/10.14735/amcsnn2017584
Overview
Cíle:
Pozitivní vliv jednotlivých dávek aminoguanidinu (AG) podaných intrahipokampálně na postižení způsobená diabetem u experimentálního zvířecího modelu diabetu již byl popsán. Cílem této studie bylo zjistit účinky 7denního intrahipokampálního podávání injekcí AG na postižení paměti vyvolané diabetem a jeho roli v apoptóze.
Materiály a metodologie:
72 samců potkanů bylo rozděleno do 9 skupin: kontrolní, kontrolní léčená fyziologickým roztokem, kontrolní léčená AG 10, 30 a 90 μg/potkana, diabetici a diabetici léčení AG 10, 30 a 90 μg/potkana. Následně bylo měřeno zvládání pasivního vyhýbání a pomocí RT-PCR geny z rodiny Bcl-2.
Výsledky:
AG významně snížil kognitivní postižení (počet opakování do osvojení si, latence udržení u step-through testu a doba strávená v zatmaveném oddíle) u diabetických potkanů. Léčba AG navíc významně ovlivnila diabetem vyvolané změny v expresi Bax, Bcl-2 a Bcl-xl.
Závěry:
Sedmidenní intrahipokampální injekční aplikace AG může zlepšit zhoršený kognitivní výkon u diabetických potkanů zvýšením Bcl-2 nebo Bcl-xl a snížením poměrů Bax.
Klíčová slova:
diabetes mellitus – aminoguanidin – hipokampus – osvojení pasivního vyhýbání – rodina genů Bcl-2
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Paediatric neurology Neurosurgery NeurologyArticle was published in
Czech and Slovak Neurology and Neurosurgery
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