#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Pilot project FLS OSTEO – Secondary prevention of osteoporotic fractures in persons aged over 50 in the Czech Republic


Authors: Němec Pavel 1,2;  Pikner Richard 3,4,7,8;  Hejduk Karel 1,2;  Ngo Ondřej 1,2;  Budíková Barbora 1;  Šanca Ondřej 1;  Palička Vladimír 4,5;  Rosa Jan 4,6;  Jarkovský Jiří 1,2;  Májek Ondřej 1,2
Authors‘ workplace: Ústav zdravotnických informací a statistiky České republiky, Národní screeningové centrum, Praha 1;  Institut biostatistiky a analýz LF MU, Brno 2;  Oddělení klinických laboratoří a kostního metabolizmu, Klatovská nemocnice, a. s., Klatovy 3;  Společnost pro metabolické onemocnění skeletu, ČLS JEP, z. s. 4;  Osteocentrum, Ústav klinické biochemie a diagnostiky LF UK a FN Hradec Králové 5;  Affidea Praha, s. r. o. 6;  Ústav klinické biochemie a hematologie LF UK a FN Plzeň 7;  Katedra záchranářství, diagnostických oborů a veřejného zdravotnictví, Fakulta zdravotnických studií, Západočeská, Univerzita v Plzni 8
Published in: Clinical Osteology 2021; 26(3): 133-142
Category:

Overview

Every third female and every fifth male over 50 years of age suffer from osteoporotic fracture. Approximately 15,000 patients with hip fracture in the Czech Republic are hospitalized every year, and nearly 25 % of them die within one year of the complications associated with this injury. Additionally, initial osteoporotic fracture increases the risk of another subsequent fracture by 2–5fold. Under-diagnosis of osteoporosis in the population is one of the most serious problems in the Czech Republic, which is related not only to the lack of information about the problem itself in the target population but also to the absence of a comprehensive program of secondary prevention of osteoporotic fractures in the Czech Republic. The ongoing national, prospective, multicenter pilot project entitled OSTEO – Secondary prevention of osteoporotic fractures in persons aged over 50 who have had their first osteoporotic fracture organized by the National Screening Centre of Institute of Health Information and Statistics of the Czech Republic aims to improve this situation. The pilot project is based on the FLS (Fraction Liaison Services) system, i.e. a coordinated search for patients with osteoporosis after a fracture, which allows to perform their subsequent differential diagnostics at the osteological centers and, if necessary, to initiate adequate treatment. The global objective of the pilot project is to verify the feasibility of implementing the FLS system in the Czech healthcare environment and to design a population-wide program for the prevention of secondary osteoporotic fractures in the Czech Republic based on this approach to ensure maximum positive impact on population health and high cost-effectiveness of the intervention.

Keywords:

Bone fracture – FLS – osteoporosis – pilot project – secondary prevention


Sources
  1. Vaculík J, Malkus T, Majerníček M, Podškubka A, Dungl P. Incidence zlomenin proximálního femuru. Ortopedie 2007; 1(2): 62–68.
  2. 2. Boonen S, Autier P, Barette M et al. Functional outcome and quality of life following hip fracture in elderly women: a prospective controlled study. Osteoporos Int 2004; 15(2): 87–94. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–003–1515-z>.
  3. Johnell O, Kanis JA, Odén A et al. Fracture risk following an osteoporotic fracture. Osteoporos Int 2004; 15(3): 175–179. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–003–1514–0>.
  4. Klotzbuecher CM, Ross PD, Landsman PB et al. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 2000; 15(4): 721–739. Dostupné z DOI: <http://dx.doi.org/10.1359/jbmr.2000.15.4.721>.
  5. Štěpán J, Vaculík J, Palička V et al. Péče o pacienty s nízkotraumatickou zlomeninou horního konce stehenní kosti. II. Následná osteologická péče. Doporučený postup České revmatologické společnosti, Společnosti pro metabolická onemocnění skeletu a České společnosti pro ortopedii a traumatologii. Osteologický bulletin 2015; 20(2): 46–56.
  6. Black DM, Cummings SR, Karpf DB et al. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 1996; 348(9041): 1535–1541. Dostupné z DOI: <http://dx.doi.org/10.1016/s0140–6736(96)07088–2>.
  7. Neer RM, Arnaud CD, Zanchetta JR et al. Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 2001; 344(19): 1434–1441. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJM200105103441904>.
  8. Reginster J, Minne HW, Sorensen OH et al. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. Osteoporos Int 2000; 11(1): 83–91. Dostupné z DOI: <http://dx.doi.org/10.1007/s001980050010>.
  9. Cummings SR, San Martin J, McClung MR et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009; 361(8): 756–765. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa0809493>.
  10. McClung MR, Geusens P, Miller PD et al. Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. N Engl J Med 2001; 344(5): 333–340. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJM200102013440503>.
  11. Harris ST, Watts NB, Genant HK et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. JAMA 1999; 282(14): 1344–1352. Dostupné z DOI: <http://dx.doi.org/10.1001/jama.282.14.1344>.
  12. Reginster JY, Seeman E, De Vernejoul MC et al. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 2005; 90(5): 2816–2822. Dostupné z DOI: <http://dx.doi.org/10.1210/jc.2004–1774>.
  13. McLellan AR, Gallacher SJ, FraserM et al. The fracture liaison service: success of a program for the evaluation and management of patients with osteoporotic fracture. Osteoporos Int 2003; 14(12): 1028–1034. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–003–1507-z>.
  14. McLellan AR, Wolowacz SE, Zimovetz EA et al. Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost-effectiveness evaluation based on data collected over 8 years of service provision. Osteoporos Int 2011; 22(7): 2083–2098. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–011–1534–0>.
  15. Marsh D, Akesson K, Beaton DE et al. Coordinator-based systems for secondary prevention in fragility fracture patients. Osteoporos Int 2011; 22(7): 2051–2065. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–011–1642-x>.
  16. Chandran M, Tan MZ, Cheen M et al. Secondary prevention of osteoporotic fractures--an „OPTIMAL“ model of care from Singapore. Osteoporos Int 2013; 24(11): 2809–2817. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–013–2368–8>.
  17. Wallace I, Callachand F, Elliott J et al. An evaluation of an enhanced fracture liaison service as the optimal model for secondary prevention of osteoporosis. JRSM Short Rep 2011; 2(2): 8. Dostupné z DOI: <http://dx.doi.org/10.1258/shorts.2010.010063>.
  18. Chakravarthy J, Ali A, Iyengar S et al. Secondary prevention of fragility fractures by orthopaedic teams in the UK: a national survey. Int J Clin Pract 2008; 62(3): 382–387. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1742–1241.2007.01662.x>.
  19. Murray AW, McQuillanC, Kennon B et al. Osteoporosis risk assessment and treatment intervention after hip or shoulder fracture. A comparison of two centres in the United Kingdom. Injury 2005; 36(9): 1080–1084. Dostupné z DOI: <http://dx.doi.org/10.1016/j.injury.2005.03.012>.
  20. Mitchell P, Åkesson K, Chandran M et al. Implementation of Models of Care for secondary osteoporotic fracture prevention and orthogeriatric Models of Care for osteoporotic hip fracture. Best Pract Res Clin Rheumatol 2 016; 3 0(3): 5 36–558. D ostupné z DOI: < http://dx.doi.org/10.1016/j.berh.2016.09.008>.
  21. Sander B, Elliot-Gibson V, Beaton DE et al. A coordinator program in post-fracture osteoporosis management improves outcomes and saves costs. J Bone Joint Surg Am 2008; 90(6): 1197–1205. Dostupné z DOI: <http://dx.doi.org/10.2106/JBJS.G.00980>.
  22. Majumdar SR, Lier DA, Beaupre LA et al., Osteoporosis case manager for patients with hip fractures: results of a cost-effectiveness analysis conducted alongside a randomized trial. Arch Intern Med 2009; 1 69(1): 2 5–31.Dostupné z DOI: < http://dx.doi.org/10.1001/archinte.169.1.25>.
  23. Harris PA, Taylor R, Thielke R et al. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009; 42(2): 377–381. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jbi.2008.08.010>.
  24. Harris PA, Taylor R, L Minor BL et al., The REDCap consortium: Building an international community of software platform partners. J Biomed Inform 2019; 95: 103208. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jbi.2019.103208>.
Labels
Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology Osteology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#