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proLékaře.cz / Journals / Clinical Osteology / 2018 - 4

Osteoporosis and fractures in multiple sclerosis: pathogenesis, risk factors, treatment options, and prevention

Czech version

Authors: Zikán Vít 1;  Kvasničková Ivana 1;  Týblová Michaela 2
Authors‘ workplace: III. interní klinika 1. LF UK a VFN v Praze 1;  Neurologická klinika 1. LF UK a VFN v Praze 2
Published in: Clinical Osteology 2018; 23(4): 146-161
Category:

Overview

Patients with neurological diseases are at higher risk of osteoporosis and fragility fractures compared to age-matched controls. This review summarizes the risk factors and pathophysiologic pathways that play a role in development of osteoporosis and fractures in multiple sclerosis (MS) patients. The research in this area has been active over recent years. Osteoporosis related fractures cause increased morbidity and mortality and add to the burden of having MS. There are currently no guidelines how to best prevent and treat osteoporosis in patients with neurological diseases. The work proposes an algorithm for the screening, prevention and treatment of osteoporosis in patients with MS.

Keywords:

Pathogenesis – Multiple sclerosis – osteoporosis – type 2 diabetes mellitus

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Labels
Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology Osteology
Eighteen months of teriparatide treatment leads to improvement of bone mineral density and trabecular bone score in patients with glucocorticoids induced osteoporosis: the results from prospective follow-up (registry OSTEO.sk)
Incidence of hip fractures in Slovakia in 2000–2016
The role of vitamin D in the treatment of secondary osteoporosis in cancer patients
Clinical perspective of RANK/RANKL/OPG system components in rheumatoid arthritis
An interdisciplinary approach to a patient with acute lymphoblastic leukemia
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