Carcinoid of the Appendix Goblet Cells Metastasize to the Orbit – a Clinical Case Report and Review of the Literature
Authors:
V. M. Matějka 1; P. Mukenšnabl 2; R. Tupý 3; O. Fiala 1; J. Fínek 1
Authors‘ workplace:
Onkologická a radioterapeutická klinika LF UK a FN Plzeň
1; Šiklův ústav patologie, LF UK a FN Plzeň
2; Klinika zobrazovacích metod LF UK a FN Plz
3
Published in:
Klin Onkol 2016; 29(3): 220-223
Category:
Case Reports
doi:
https://doi.org/10.14735/amko2016220
Overview
Goblet cell carcinoid (GCC) of the appendix is extremely rare, representing approximately 5% of all primary appendiceal neoplasms. Histologically there are three groups of GCC: group A (typical GCC), adenocarcinoma ex GCC signet ring cell type (group B), and adenocarcinoma ex GCC poorly differentiated carcinoma type (group C), which is the most aggressive. GCC metastasizes in 15–60% of cases, mainly to the ovaries, pelvis, abdominal cavity, ribs, vertebrae, and lymph nodes. Hematogenous metastasis to the liver or other parenchymal organs can occur, but this is very rare. The different organs metastases haven’t been described yet. The primary mode of treatment is radical surgical resection or debulking, followed by chemotherapy; however, patients with unresectable or recurrent GCC are candidates for systemic therapy. Here, we report a case of very aggressive GCC of the appendix, which had metastazed to the liver at the time of diagnosis and subsequently metastasized to the orbit.
Key words:
carcinoid tumor – goblet cells – metastatic – appendix – orbit
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.
Submitted:
2. 2. 2016
Accepted:
25. 4. 2016
Sources
1. McGory ML, Maggard MA, Kang H et al. Malignancies of the appendix: beyond case series reports. Dis Colon Rectum 2005; 48(12): 2264– 2271.
2. McCusaker ME, Coté TR, Clegg LX et al. Primary malignant neoplasms of the appendic: a population-based study from the surveillance, epidemiology and end results program 1973– 1998. Cancer 2002; 94(12): 3307– 3312.
3. Anderson NH, Somerville JE, Johnston CF et al. Appendiceal goblet cell carcinoids: a clinicopathological and immunohistochemical study. Histopathology 1991; 18(1): 61– 65.
4. Tang LH, Shia J, Soslow RA et al. Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol 2008; 32(10): 1429– 1443.
5. Toumpanakis C, Standish RA, Baishnab E et al. Goblet cell carcinoid tumors (adenocarcinoid) of the appendix. Dis Colon Rectum 2007; 50(3): 315– 322.
6. Mitra B, Pal M, Paul B et al. Goblet cell carcinoid of appendix: a rare case with literature review. Int J Surg Case Rep 2013; 4(3): 334– 337. doi: 10.1016/ j.ijscr.2013.01.007.
7. Roy P, Chetty R. Goblet cell carcinoid tumors of the appendix: an overview. World J Gastrointest Oncol 2010; 2(6): 251– 258. doi: 10.4251/ wjgo.v2.i6.251.
8. Stancu M, Wu TT, Wallace C et al. Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors. Mod Pathol 2003; 16(12): 1189– 1198.
9. Pham TH, Wolff B, Abraham SC et al. Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. Ann Surg Oncol 2006; 13(3): 370– 376.
10. Butler JA, Houshiar A, Lin F et al. Goblet cell carcinoid of the appendix. Am J Surg 1994; 168(6): 685– 687.
Labels
Paediatric clinical oncology Surgery Clinical oncologyArticle was published in
Clinical Oncology
2016 Issue 3
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