Odhad glomerulární filtrace u pacientů s diabetem

English version Czech version

: T. Šálek ¹; P. Ponížil ^2,3
: Department of Clinical Biochemistry, Tomas Bata Regional Hospital in Zlín a. s., Havlíčkovo nábřeží 600, 76 75 Zlín, Czech Republic ¹; Centre of Polymer Systems, Polymer Centre, Tomas Bata University in Zlín, Náměstí T. G. M. 5555, 760 05 Zlín, Czech Republic ²; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University at Zlín, Náměstí T. G. M. 275, 762 72 Zlín, Czech Republic ³
: Klin. Biochem. Metab., 22 (43), 2014, No. 1, p. 4-7

Cíl studie:
Cílem studie je porovnat odhadovanou glomerulární filtraci (eGFR) ze sérového kreatininu (eGFR_creatinine) a cystatinu C (eGFR_{cystatin C}) a studovat dopad těchto odhadů na detekci a klasifikaci chronického onemocnění ledvin (CKD) u pacientů s diabetes mellitus.

Typ studie:
retrospektivní průřezová

Název a sídlo pracoviště:
Oddělení klinické biochemie, Krajská nemocnice T. Bati a. s. Havlíčkovo nábřeží 600, Zlín 762 75

Materiál a metody:
Studovanou populaci tvořilo 565 po sobě jdoucích diabetiků z diabetické ambulance Krajské nemocnice Tomáše Bati ve Zlíně. Sérový kreatinin a cystatin C jsme měřili standardizovanými metodami a eGFR byla počítána podle Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) rovnic, které byly vytvořeny v roce 2012. CKD je definováno jako GFR pod 1,0 ml/s/1,73m².

Výsledky:
Průměrná eGFR_creatinine (1,443 ± 0,014) ml/s/1,73m² byla nižší než eGFR_cystatin C(1,512 ± 0,017) ml/s/1,73m², (p < 0,002). Našli jsme malou shodu v detekci CKD mezi eGFR_creatinine a eGFR_{cystatin C}. Rozdílná detekce byla u 38 pacientů.

Závěr:
Průměrná eGFR_{cystatin C} byla významně vyšší než eGFR_creatinine. eGFR_{cystatin C} dává větší průměrné hodnoty než eGFR_creatinine, hlavně v oblasti eGFR nad 1,5 ml/s/1,73m². Naše výsledky podporují společné používání eGFR_{cystatin C}a eGFR_{creatinine+cystatin C} u pacientů s diabetes mellitus bez albuminurie nebo jiného markeru poškození ledvin ve stadiu GFR 2 a 3a podle eGFR_creatinine.

Klíčová slova:
kreatinin, cystatin C, glomerulární filtrace, chronické onemocnění ledvin, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)

Sources

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Labels

Clinical biochemistry Nuclear medicine Nutritive therapist

Estimated glomerular filtration rate and problems in the interpretation of CKD-EPI equations. (Short communication - data expansion and comments to the article „Estimated glomerular filtration rate in diabetic patients“ published by Šálek, T. and Ponížil, P.)

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Article was published in

Clinical Biochemistry and Metabolism

2014 Issue 1