#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

New generation of hs cardiac troponins and diagnosis of acute coronar syndrome - minireview


Authors: B. Friedecký 1,2;  J. Kratochvíla 1
Authors‘ workplace: SEKK spol. s. r. o., Pardubice 1;  ÚKBD FN Hradec Králové 2
Published in: Klin. Biochem. Metab., 21 (42), 2013, No. 4, p. 190-196

Overview

Our publication deals with data obtained from recently published literature in situation releasing the high sensitivity (hs) cTn methods on the market after their FDA clearance. These methods are 10 - 100x more analytically sensitive and lead to a large increase of quantitative results in reference population. Due to increased analytical sensitivity emerged problems with interpretation of sex and age influences on diagnostic limits, using new units, timing of sample collection, necessity of reduction used cardiac markers in routine diagnostic process.

Keywords:
Cardiac troponins, hs methods, universal definition of acute my cardial infarction, role of sex, reference population.


Sources

1. Thygesen, K., Alpert, J., Jaffe, A. S., Simons, M. L., Chaitman, B. R., White, H. D. et al. Third Universal Definition of Myocardial Infarction. Circulation, 2012, 126, p. 2020-2035. (Již zmiňuje hs metody)

2. Jaffe, A. S., Apple, F. S. The Third Universal Definition of Myocardial Infarction -Moving Forward. Clin. Chem., 2012, 58, p. 1727-1728.

3. Apple, F. S., Collinson, P. O. Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays. Clin. Chem., 2012, 58, p. 54-61.

4. Apple, F. S., Ler, R., Murakami, M. A. Determination of 19 Cardiac Troponin I and T Assay. 99th Percentile Values from a Commom Presumably Healthy Population. Clin. Chem., 2012, 58, p. 1574-1581.

5. Cardinaels, E. P. M., Mingels, A. M. A., Jacobs, L. H. J., Meex, S. R. J., Bekers, D. et al. A comprehensive rewiew of upper reference limits reported for (high) sensitivity cardiac troponin assays: the challenges that lies ahead. Clin. Chem. Lab. Med., 2012, 50, p. 791-806.

6. Thygesen, K., Mair, J., Gianitis, E., Mueller, Ch., Lindahl, B. et al. How to use high-sensitivity cardiac troponins in acute cardiac case. Eur. Heart. J., 2012, 33, p. 2252-2257.

7. Mueller, M., Biever, M., Vafaic, D., Dorr, S., Keller, T. et al. Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome. Clin. Chem., 2012, 58, p. 209-218

8. Reichlin, T., Irfan, A., Twerenbold, R., Reiter, M., Hochholzer, W. et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation, 2011, 127, p. 136-145

9. Collinson, P. O., Van Diejnen Visser, M. P., Pulkki, K., Hammerer-Lercher, A., Suivissari, J. et al. Evidence based laboratory medicine: how well do laboratories follow recommendations and guidelines? The cardiac marker guideline uptake in Europe (CARMAGUE). Clin. Chem., 2012, 58, p. 305-316

10. Thygesen, K., Mair, J., Katus, H., Plebani, M., Venge, P. et al. Recommendations for the use of cardiac troponin measurement in acute cardiac case. Eur. Heart. J., 2010, 31, p. 2197-2206.

11. Newby, L. K., Jesse, R. L., Babb, J. D., Christenson, R. H., De Fer, T. M. et al. ACCF 2012 expert consensus document on practical clinical considerations in the interpretation of troponin elevation: a report of the American College of Cardiology Foundation task force on Clinical Expert Consensus Documents. J. Am. Coll. Cardiol., 2012, 60/23, p. 2427-2463.

12. Rollins, G. New practical guidance for cardiac troponin. How can laboratorians help physicians? Clin. Lab. News, 2013, 39/2 (ke dni 4. 9. 2013 dostupné na www.aacc.org).

13. Casagranda, I., Cavazza, M., Clerico, A., Galvani, M., Ottani, F. et al. Proposal for the use in emergency departments of cardiac troponins measured with the latest generation methods in patients with suspected acure coronary syndrome without persistent ST-segmant elevation. Clin. Chem. Lab. Med. (v tisku DOI 10. 15. 15/cclm-2013-0423).

14. Thomas, S., Kavsak, P., Deveraux, P. J. Cardiac Troponin-Clinical Considerations per High-Sensitivity Assays. Clin. Lab. News, 2013, 39/4 (ke dni 4. 9. 2013 dostupné na www.aacc.org).

15. Lippi, G., Cervellin, G. Do we really need high-sensitivity troponin immunoassays in the emergency department? Clin. Chem. Lab. Med., 2013 (v tisku DOI 1515/cclm-2013-0524).

16. Hammerer-Lercher, A., Ploner, T., Naururer, S., Schvartzberger, P., Griesemacher, A. et al. High-sensitivity cardiac troponin T compared with standard troponin T testing on emergency department admision: How much does it add in every day practices? J. Am. Heart. Assoc., 2013, 2/3, p. 1-11.

17. Lackner, K. J. Do we really need high-sensitivity troponin immunoassays in the emergency department? Definitely, yes. Clin. Chem. Lab. Med., 2013 (v tisku DOI 10. 1515/cclm-2013-0604).

18. Apple, F. S., Saenger, A. K. The state of cardiac troponin assays: looking bright and moving in the right direction. Clin. Chem., 2013, 59/7, p. 1014-1016.

19. Tate, J. Standardization of cTnI. Is there a light at the end of the tunnel? CIRME, Euromedlab Milano, May 24, 2013.

20. Sandoval, Y., Apple, F. S. The global need to define normality: the 99th percentile value of cardiac troponin. Clin. Chem., 2013, http://hwmaint.clinchem.org/cgi/doi/10. 1373/clinchem. 2013. 211706

21. Savyer, N., Blennerhasset, N., Lambert, R., Sheehan, P., Vasikaran, S. D. Outliers affecting cardiac troponin I measurement-comparison of a new high sensitivity assay with a contemporary assay on the Abbott Architect analyzer. Ann. Clin. Biochem., 2013, http://acbsagepub. com/content/early/2013/09/20/0004563213499737

Labels
Clinical biochemistry Nuclear medicine Nutritive therapist
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#