Cerebrospinal fluid analysis in the diagnosis of subarachnoid hemorrhage

Czech version

Authors: P. Brož; J. Ženková; K. Řezáčová
Authors‘ workplace: Ústav klinické biochemie a hematologie Lékařské fakulty UK a Fakultní nemocnice v Plzni.
Published in: Klin. Biochem. Metab., 21 (42), 2013, No. 4, p. 220-225

Overview

Subarachnoid hemorrhage (SAH) is a serious, life-threatening cause of morbidity and mortality in the world. Despite the progression in imaging and laboratory methods remain a significant percentage of patients with SAH misdiagnosed. Virtual unenhanced CT of the brain is the investigation of choice for establishing presence of SAH. Cerebrospinal fluid (CSF) spectrophotometry is recommended in CT negative patients, when clinical suspicion remains high. The specimen for spectrophotometry has certain requirements for the collection, handling and transport to the laboratory, however, can be a valuable diagnostic tool. According to recent recommendations is appropriate to interpret the result using serum protein, serum bilirubin and CSF protein levels. In addition to CSF spectrophotometric examination other laboratory tests as CSF cytology, red cell count examination or CSF ferritin levels can be useful.

Keywords:
subarachnoid hemorrhage, cerebrospinal fluid spectrophotometry, cytology, ferritin.

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Article was published in

Clinical Biochemistry and Metabolism

2013 Issue 4