Screening of asymptomatic carotid atherosclerosis in diabetic patients and its association with ankle-brachial index
Authors:
Homza M. 1; Machaczka O. 2; Porzer M. 1,3; Kozák M. 4; Plášek J. 1,2; Šipula D. 1,2
Authors‘ workplace:
Katedra interních oborů, LF OU, Ostrava
1; Ústav epidemiologie a veřejného zdraví, LF OU, Ostrava
2; Kardiovaskulární oddělení, FN Ostrava
3; Interní kardiologická klinika LF MU a FN Brno
4
Published in:
Kardiol Rev Int Med 2019, 21(1): 24-28
Overview
Asymptomatic carotid atherosclerosis remains a relatively controversial topic with respect to both interventional therapy and recommendations for the use of diagnostic ultrasound. In our study, a group of high risk diabetic patients attending a cardiovascular clinic was examined using duplex ultrasound for carotid atherosclerosis and the results were compared with lower extremity arterial disease (LEAD) and the ankle-brachial index (ABI) obtained using the lower of ankle pressures. Carotid atherosclerosis was detected in 87.1% of patients, 27.4% of which had a stenosis of more than 50%, and significant stenosis (i.e., greater than 70%) was detected in 9.7% of patients. These numbers were even higher in the group of patients over 60 years of age. We also revealed a strong relationship between LEAD and significant carotid stenosis as well as between the ABI value, calculated using the lower arterial pressure, and significant carotid stenosis. No patient with normal ABI and no patient without LEAD had significant carotid stenosis. Hence, we conclude that it is beneficial to perform ABI measurement using Doppler ultrasound method and lower arterial pressure at the ankle level that can also serve, as well as the LEAD screening, as a useful tool for determining whether or not a duplex examination of carotids should be performed in the particular patient.
Keywords:
atherosclerosis – carotids – ankle-brachial index – ABI – lower extremity arterial disease – peripheral arterial disease – duplex ultrasonography
Sources
1. Ryden L, Grant PJ, Anker SD et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J 2013; 34(39): 3035– 3087. doi: 10.1093/ eurheartj/ eht108.
2. Bosevski M. Carotid artery disease in diabetic patients. Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2014; 35(3): 149– 161.
3. Spacek M, Zemanek D, Hutyra M et al. Vulnerable atherosclerotic plaque – a review of current concepts and advanced imaging. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018; 162(1): 10– 17. doi: 10.5507/ bp.2018.004.
4. Brott TG, Halperin JL, Abbara S et al. 2011 ASA/ ACCF/ AHA/ AANN/ AANS/ ACR/ ASNR/ CNS/ SAIP/ SCAI/ SIR/ SNIS/ SVM/ SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: executive summary: a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines, and the American Stroke Association, American Association of Neuroscience Nurses, American Association of Neurological Surgeons, American College of Radiology, American Society of Neuroradiology, Congress of Neurological Surgeons, Society of Atherosclerosis Imaging and Prevention, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of NeuroInterventional Surgery, Society for Vascular Medicine, and Society for Vascular Surgery. Vasc Med 2011; 16(1): 35– 77. doi: 10.1177/ 1358863X11399328.
5. Barnett HJ, Taylor DW, Haynes RB et al. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 1991; 325(7): 445– 453. doi: 10.1056/ NEJM199108153250701.
6. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998; 351(9113): 1379– 1387.
7. Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 1995; 273(18): 1421– 1428.
8. Halliday A, Mansfield A, Marro J et al. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 2004; 363(9420): 1491– 1502. doi: 10.1016/ S0140-6736(04)16146-1.
9. Brott TG, Hobson RW 2nd, Howard G et al. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med 2010; 363(1): 11– 23. doi: 10.1056/ NEJMoa0912321.
10. Cheng SF, Brown MM. Contemporary medical therapies of atherosclerotic carotid artery disease. Semin Vasc Surg 2017; 30(1): 8– 16. doi: 10.1053/ j.semvascsurg.2017.04.005.
11. Rooke TW et al. 2011 ACCF/ AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation/ American Heart Association Task Force on practice guidelines. Circulation 2011; 124(18): 2020– 2045. doi: 10.1161/ CIR.0b013e31822e80c3.
12. American Diabetes Association. Peripheral arterial disease in people with diabetes. Diabetes Care 2003; 26(12): 3333– 3341.
13. Gerhard-Herman MD, Gornik HL, Barrett C et al. 2016 AHA/ ACC Guideline on the management of patients with lower extremity peripheral artery disease: executive summary: a report of the American College of Cardiology/ American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2017; 69(11): 1465– 1508. doi: 10.1016/ j.jacc.2016.11.008.
14. Newman AB, Siscovick DS, Manolio TA et al. Ankle-arm index as a marker of atherosclerosis in the Cardiovascular Health Study. Cardiovascular Heart Study (CHS) Collaborative Research Group. Circulation 1993; 88(3): 837– 845.
15. McDermott MM, Liu K, Criqui MH et al. Ankle-brachial index and subclinical cardiac and carotid disease: the multi-ethnic study of atherosclerosis. Am J Epidemiol 2005; 162(1): 33– 41. doi: 10.1093/ aje/ kwi167.
16. Cina CS, Safar HA, Maggisano R et al. Prevalence and progression of internal carotid artery stenosis in patients with peripheral arterial occlusive disease. J Vasc Surg 2002; 36(1): 75– 82.
17. Školoudík D, Škoda O, Bar M et al. Neurosonologie. 1. vyd. Praha: Galén 2003.
18. Aboyans V, Criqui MH, Abraham P et al. Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association. Circulation 2012; 126(24): 2890– 2909. doi: 10.1161/ CIR.0b013e318276fbcb.
19. Raman G, Moorthy D, Hadar N et al. Management strategies for asymptomatic carotid stenosis: a systematic review and meta-analysis. Ann Intern Med 2013; 158(9): 676– 685. doi: 10.7326/ 0003-4819-158-9-201305070-00007.
20. Araki Y, Kumakura H, Kanai H et al. Prevalence and risk factors for cerebral infarction and carotid artery stenosis in peripheral arterial disease. Atherosclerosis 2012; 223(2): 473– 477. doi: 10.1016/ j.atherosclerosis.2012.05.019.
21. Bez LG, Navarro TP. Study of carotid disease in patients with peripheral artery disease. Rev Col Bras Cir 2014; 41(5): 311– 318.
22. Bavil AS, Ghabili K, Daneshmand SE et al. Prevalence of significant carotid artery stenosis in Iranian patients with peripheral arterial disease. Vasc Health Risk Manag 2011; 7: 629– 632. doi: 10.2147/ VHRM.S23979.
23. Duval M, Altman JJ. When should ultrasonography be used to detect asymptomatic carotid atheroma in diabetic patients? Diabetes Metab 2006; 32(6): 638– 642.
Labels
Paediatric cardiology Internal medicine Cardiac surgery CardiologyArticle was published in
Cardiology Review
2019 Issue 1
Most read in this issue
- Comparison of the benefits of FGM and CGM for different clinical scenarios in patients with type 1 diabetes mellitus
- The role of nebivolol in the treatment of cardiovascular diseases
- The most common causes of hospitalisation and death in patients with diabetes – results of the National Diabetology Registry
- Screening of asymptomatic carotid atherosclerosis in diabetic patients and its association with ankle-brachial index