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Implementation of Guidelines for Diagnosis and Treatment of Heart Failure 2016 in clinical practice – the role of ivabradine


Authors: F. Málek
Authors‘ workplace: Kardiocentrum, Nemocnice Na Homolce, Praha
Published in: Kardiol Rev Int Med 2017, 19(2): 123-127

Overview

We present two clinical cases documenting an application of the current Guidelines for Diagnosis and Treatment of Heart Failure issued by the European Society of Cardiology. The treatment algorithm recommends gradual use of disease modifying drug with dose titration to maximal tolerated doses. These drugs include angiotensin converting enzyme inhibitors or angiotensin receptor blockers, betablockers, mineralocorticoid antagonists, which are used together with diuretics to eliminate the symptoms of congestion. In case of persisting symptoms, ivabradin is one of possible further steps.

Keywords:
heart failure with reduced ejection fraction – ivabradine


Sources

1. Špinar J, Hradec J, Špinarová L et al. Souhrn doporučených postupů ESC pro dia­gnostiku a léčbu akutního a chronického srdečního selhání z roku 2016. Cor Vasa 2016; 58(5): e530– e568.

2. Swedberg K, Komajda M, Bohm M et al. Ivabradin and outcomes in chronic heart fail­ure (SHIFT): a randomised placebo –  control­led trial. Lancet 2010; 376(9744): 875– 885. doi: 10.1016/ S0140-6736(10)61198-1.

3. Borer JS, Böhm M, Ford I et al. Ef­fect of ivabradine on recur­rent hospitalization for worsen­ing heart fail­ure in patients with chronic systolic heart silure: the SHIFT Study. Eur Heart J 2012; 33(2): 2813– 2820. doi: 10.1093/ eurheartj/ ehs259.

4. Tavazzi L, Swedberg K, Komajda M et al. Ef­ficacy and safety of ivabradine in chronic heart failure across the age spectrum: Insights from the SHIFT study. Eur J Heart Fail 2013; 15(11): 1296– 1303. doi: 10.1093/ eurjhf/ hft102.

5. Volter­rani M, Cice G, Caminiti G et al. Ef­fect of Carvedilol, Ivabradine or their combination on exercise capacity in patients with Heart Failure (the CARVIVA HF trial). Int J Cardiol 2011; 151(2): 218– 224. doi: 10.1016/ j.ijcard.2011.06.098.

Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
Topics Journals
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