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Irritable bowel syndrome –  dia­gnosis and treatment


Authors: J. Ehrmann 1;  K. Urbánek 2
Authors‘ workplace: II. interní klinika –  gastro‑enterologická a hepatologická LF UP a FN Olomouc 1;  Ústav farmakologie, LF UP a FN Olomouc 2
Published in: Kardiol Rev Int Med 2014, 16(3): 224-228
Category: Internal Medicine

Overview

Irritable bowel syndrome (IBS) and functional dyspepsia are the most common functional gut disorders. The main topic of the article is a summary review of the aetiology and pathogenesis of this disease as well as its dia­gnostic procedures and treatment. Irritable bowel syndrome is characterized by abdomen pain with altered stool frequency or consistency. It is recommended that it be defined and classified according to the Rome III classification. The symptoms are induced by physiological aberrations (like dysmotility and visceral hypersensitivity) or by the mechanisms of the initial inflammation and neuro‑immune inter­action. This is also the focus of contemporary research. The aetiology and pathogenesis, however, remain unclear and the therapy of the day remains at the level of decreasing the main symptoms: abdominal pain, constipation, diarrhoea and psychological factors. Sulpiride, an antagonist of the D1 and D3 receptors, at a dose of 50 or 100 mg 3 times daily should be a first– choice treatment of IBS due to its anxiolytic and analgesic effects. The adverse effects of drugs for the treatment of IBS on the cardiovascular system are discussed in the last part of the article.

Keywords:
irritable bowel syndrome –  classification –  dia­gnosis –  treatment


Sources

1. Thomayer J. Pathologie a Therapie Nemocí Vnitřních. Praha: Bursík & Kohout 1921; 831– 832.

2. Thompson WG, Longstreth G, Drossman DA et al. Functional bowel disorders and functional abdominal pain. Gut 1999; 45 (Suppl 2): II43– II47.

3. Thompson WG. Irritable Bowel Syndrome. In: Drossman DA (ed). The Functional Gastrointestinal Disorders Rome II. 2nd ed. Virginia USA: Denon Associates McLean 2000; 355– 375.

4. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006; 130: 1337– 1390.

5. Bureš J. Neměli bychom léčit Římská kriteria ale pacienta. Čes a Slov Gastroent a Hepatol 2008; 62: 139– 141.

6. Torsoli A et. al. Working Team Reports. Gastroenterol Internat 1991; 4: 189– 190.

7. Almy TP. Digestive disease as a national problem. II. A white paper by the American Gastroenterological Association. Gastroenterology 1967; 53: 821– 833.

8. Thompson WG. Gender differences in irritable bowel symptoms. Eur J Gastroenterol Hepatol 1997; 9: 299– 302.

9. Akbar A, Walter JR, Ghosh S. Review artical: visceral hypersensitivity in irritable bowel syndrome: molecular mechanisms and therapeutic agens. Aliment Pharmacol Ther 2009; 30: 423– 435. doi: 10.1111/ j.1365‑ 2036.2009.04056.x.

10. Ritchie J. Pain from distension of the colon by inflanting a balloon in the irritable colon syndrome. Gut 1973; 14: 125– 132.

11. Serra J, Azpiroz F, Malagelada JR. Impaired transit and tolerance of intestina gas in the irritable bowel syndrome. Gut 2001; 48: 14– 19.

12. Herschbach P, Henrich G, von Rad M. Psychological factors in functional gastrointestinal disorders: characteristic of the disorder or of the illness behaviour? Psychosom Med 199; 61: 148– 153.

13. Chaudhary NA, Truelove SC. The irritable colon syndrome. A study of the clinical features, predisponsing causes and prognosis in 130 causes. Q J Med 1962; 31: 307– 322.

14. Barbara G, De Giorgio R, Deng Y et al. Role of immunologic factors and cyclooxygenase 2 in persistent postinfective enteric muscle dysfunction in mice. Gastroenterology 2001; 120: 1729– 1736.

15. Isgar B, Harman M, Kaye MD et al. Symptoms of irritable bowel syndrome in ulcerative colitis in remission. Gut 1983; 24: 190– 192.

16. Dunlop SP, Jenkins D, Spiller RC. Distinctive clinical, psychological, and histological feature of postinfective irritable bowel syndrome. Am J Gastroenterology 2003; 98: 1578– 1583.

17. Cremonini F, Talley NJ. Review article: the owerlap between functional irritable bowel syndrome –  a tale of one or two disorders? Aliment Pharmacol Ther 2004; 20 (Suppl 7): 40– 49.

18. Inadomi JM, Fennerty MB, Björkman D. Systematic review: the ecomomic impact of irritable bovel syndrome. Aliment Pharmacol Ther 2003; 18: 671– 682.

19. Lucini D, Pagani M. From stress to functional syndromes: an internist's point of view. Eur J Intern Med 2012; 23: 295– 301. doi: 10.1016/ j.ejim.2011.11.016.

20. Hilgard ER. Hypnotic Susceptibility. NY USA: Brace & World. Inc. 1965.

21. Kratochvíl S. Gastrointestinální poruchy. In: Kratochvíl S. (ed) Klinická hypnóza. 2. vyd.; Praha: Grada Publishing 2001: 186– 192.

22. Honzák R. Pohled psychiatra na funkční poruchy trávicího systému. In: Lukáš K et al. (eds). Funkční poruchy trávicího trakt. Praha: Grada Publishing 2003: 174– 192.

23. Sweetman SC (ed). Martindale: The Complete Drug Reference. 37th ed. London: Pharmaceutical Press 2011.

24. Stöllberger C, Huber JO, Finsterer J. Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol 2005; 20: 243– 251.

25. Tisdale JE, Miler DA. Drug‑Induced Diseases: Prevention, Detection, and Management (2nd Ed) Bethesda: American Society of Health- System Pharmacists 2010.

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