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Coeliac disease


Authors: Přemysl Falt 1,2;  P. Fojtík 1;  V. Šmajstrla 1
Authors‘ workplace: Centrum péče o zažívací trakt, Vítkovická nemocnice, Ostrava 1;  LF OU v Ostravě 2
Published in: Kardiol Rev Int Med 2014, 16(3): 219-223
Category: Internal Medicine

Overview

Coeliac disease is a common lifelong autoimmune disorder triggered by gluten consumption in genetically predisposed patients. Chronic inflammatory res­ponse damages the mucosa of the small intestine resulting in villous atrophy with chronic maldigestion and malabsorption. Untreated coeliac disease may present with a variety of intestinal and extraintestinal symptoms and complications, the most serious of which is a small intestine lymphoma. The dia­gnosis is usually established by specific serology markers and villous atrophy in duodenal bio­psy. The causal and, in most cases, effective treatment modality is a strict and life‑ long gluten‑free diet that leads to regeneration of the intestinal mucosa and reduces the risk of serious complications.

Keywords:
coeliac disease –  gluten –  malabsorption –  gluten‑free diet


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