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Affect statin myopathy reduced form of coenzyme Q10?


Authors: L. Zlatohlávek;  R. Češka
Published in: Kardiol Rev Int Med 2012, 14(4): 273-276
Category:

Overview

Background:
Statins significantly reduce CV morbidity and mortality. Unfortunately, one of the side effects of statins is myopathy, for which statins can not be administered in sufficient doses or administered at all.

Aim:
The aim of this study was to demonstrate the effect of coenzyme Q10 in patients with statin myopathy.

Methods:
28 patients (18 women and 10 men, aged 60.6 ± 10.7) were investigated and treated with different types of statins (atorvastatin, simvastatin, rosuvastatin, fluvastatin, pravastatin and lovastatin). Muscle weakness and pain were monitored using a scale of one to ten, on which patients expressed the degree of their problems. Examination of muscle problems was performed prior to administration of 60 mg per day reduced coenzyme Q10 and after 3 and 6 months of dosing. Statistical analysis was performed.

Results:
Pain decreased on average by 53.8% (p < 0.0001), muscle weakness by 44.4% (p < 0.0001). The Q10 levels were increased by more than 194% (from 0,903 μg/ml to 2.66 μg/ml; p < 0.0001).

Conclusion:
After a six-month administration of reduced form of coenzyme Q10, muscle pain and sensitivity statistically significantly decreased.

Keywords:
statin – statin myopathy – muscle pain – muscle weakness – reduced form of koenzym Q10


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