How are we doing in achieving target LDL-cholesterol levels in the high-risk population in Slovakia: retrospective study

Czech version

Authors: Štefan Tóth ^1,2; Daniel Pella ³
Authors‘ workplace: SLOVACRIN, LF Univerzity Pavla Jozefa Šafárika v Košiciach ¹; MEDIPARK, LF Univerzity Pavla Jozefa Šafárika v Košiciach ²; II. kardiologická klinika LF Univerzity Pavla Jozefa Šafárika a Východoslovenský ústav srdcových a cievnych chorôb, a. s., Košice ³
Published in: AtheroRev 2022; 7(2): 110-115
Category: Clinical Studies

Overview

Introduction: Despite significant progress in the management of cardiovascular (CV) diseases, they represent the most common cause of morbidity and mortality. LDL-cholesterol (LDL-C) reduction is a basic pillar of primary as well as secondary prevention of heart disease. The Aim of this study was to monitor LDL-C concentrations in patients at very high CV risk and to determine the prevalence of patients reaching the LDL-C target values. Methodology: This project took place in the form of a retrospective analysis of anonymized LDL-C values from 2017–2019 from the data of cooperating laboratory with nationwide operations. Overall, patients with a diagnosis of an acute coronary syndrome (ACS), stroke and a general patient with a very high CV risk were included. The LDL-C target values were evaluated based on the then valid ESC/EAS 2016 recommendations. Results: A total of 220,657 LDL-C results from 72,039 patients were obtained. In patients with ACS, LDL-C target values were achieved by only 8–9 % of patients in each year of follow-up. Up to 6–9 % of patients have LDL-C levels ≥ 4.9 mmol/L. In the case of patients with stroke, only 9–10 % of patients achieved target values and 7–8 % had levels ≥ 4.9 mmol/L. In the group with very high CV risk, only 7 % of patients reached the target levels and 7–8 % had extremely high LDL-C values ≥ 4.9 mmol/L. In the case of the application of the new ESC/EAS 2019 recommendations, the target levels were reached by only 2–3 % of patients. Conclusion: Based on the results of the analysis, we found that up to 90 % of patients at very high CV risk do not reach the target LDL-C values. These patients remain at high risk for further CV events and would benefit significantly from intensified hypolipidemic therapy.

Keywords:

dyslipidemia – cardiovascular risk – target values – LDL-cholesterol – retrospective analysis

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