Cancer treatment as a non-traditional risk factor for atherosclerosis

Czech version

Authors: Pavel Kraml ^1,2,3
Authors‘ workplace: Centrum pro výzkum diabetu, metabolismu a výživy 3. LF UK a FN Královské Vinohrady, Praha ¹; Centrum pro diagnostiku a léčbu hyperlipoproteinemií 3. LF UK a FN Královské Vinohrady, Praha ²; Interní klinika 3. LF UK a FN Královské Vinohrady, Praha ³
Published in: AtheroRev 2022; 7(2): 76-81
Category: Reviews

Overview

The prognosis of patients with oncological diseases is significantly improving due to the modern therapeutic options. More and more patients achieve remission, however their cardiovascular risk is increasing. In fact, all types of oncology treatment (radiotherapy, chemotherapy, hormonal therapy, biological therapy, stem cell transplant) may accelerate atherosclerosis, either by their toxic effect on arterial endothelium or through oxidative stress, proinflammatory state and insulin resistance. For cardiovascular risk assessment in these patients we have to evaluate not only the traditional risk factors but also the impact of oncological treatment, which can be difficult in some therapeutics, especially the modern ones with not sufficient data available. During the oncological therapy as well as in remission, patients with preexisting cardiovascular disease or those with cumulation of traditional risk factors should be observed by team of specialists involving both oncologists and cardiologists. However, definite and unanimous guidelines reflecting type of the oncology disease, the length and intensity of each therapeutic modality, the age of the patient or duration of remission are still lacking, both for the secondary as well as the primary prevention of atherosclerotic cardiovascular diseases (ASCVD).

Keywords:

Atherosclerosis – cardiovascular risk – cardio-oncology – oncology therapy

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