The principles of opioid‑free anesthesia and postoperative analgesia, our experience in bariatric surgery
Authors:
P. Píza; E. Uchytilová; A. Čermáková; E. Kieslichová
Authors‘ workplace:
The principles of opioid‑‑free anesthesia and postoperative analgesia, our experience in bariatric surgery
Published in:
Anest. intenziv. Med., 33, 2022, č. 1, s. 25-31
Category:
Review Article
Overview
Opioid-free anaesthesia and postoperative analgesia are methods of perioperative care without the use of opioids, whereas the principles of opioid-sparing anaesthesia and postoperative analgesia lie in the use of opioids in minimal doses. These methods are based on multimodal approach and reduce the influence of opioid side-effects on postoperative course. Within general opiod-free anaesthesia and systemic postoperative analgesia a combination of adjuvant, non-opioid analgetics and non-steroidal antiinflammatory drugs is used, which enables to reduce opioid consumption and the incidence of opioid side effects. NMDA receptor antagonists, local anaesthetics and α2-receptor agonists are the most frequenly used drugs. Benefit of opioid-free anaethesia and analgesia was primarily shown in patients, for whom opioid side-effects mean significant risk of postoperative complications, for example morbidly obese patients undergoing bariatric surgical procedures. In our institute opioid-free approach proved to be effective and beneficial in patients undergoing laparoscopic assisted sleeve gastrectomies. Even though it is not possible to recommend opioid-free anaesthesia and analgesia as a method of choice in general, opioid-sparing approach is a fixed part of guidelines for anaesthesia and postoperative analgesia in risk patients, who are seriously endangered by opioid side-effects.
Keywords:
opioids – opioid‑ free anaesthesia – opioid‑sparing anaesthesia – mulimodal systemic analgesia
Sources
1. Sultana A, Torres D and Schumann R. Special indications for Opioid Free Anaesthesia and Analgesia, patient and procedure related: Incluidng obesity, sleep apnoea, chronic obstructive pulmonary disease, complex regional pain syndromes, opioid addivtion and cancer surgery. Best Practice & Research Clinical Anaesthesiology 31 (2017) 547-560.
2. Dahl JB, Rosenberg J, Dirkes WE, Mogensen T, Kehlet H. Prevention of postoperative pain by balanced analgesia. Br J Anaesth 1990;64:518-520.
3. Beloeil H. Opioid‑free anesthesia. Best Practice & Research Clinical Anaesthesiology 33 (2019)353-360.
4. Egan TD. Are opioids indispensable for general anesthesia? Br J Anesth 2019;122:e127-35.
5. Kaye AD, Granier AL, Garcia AJ, Carlson SF, Fuller MC, Haroldson AR et al. Non‑Opioid Perioperative Pain Strategies for the Clinician: A Narrative Review Pain Ther. 2020 Jun;9(1):25-3.
6. Dunkman WJ, Manning MW. Enhanced Recovery After Surgery and Multimodal Strategies for Analgesia Surg Clin North AM. 2018 Dec;98(6):1171-1184.
7. Koepke EJ, Manning EL, Miller TE, Ganesh A, Williams DG, Manning MW. The rising tide of opioid use and abuse: The role of the anesthesiologist. Perioper Med. 2018;7:16.
8. Thota RS, Ramkiran S, Garg R, Goswami J, Baxi V, Thomas M. Opioid free onco‑anesthesia: Is it time to convict opioids? A systematic review of literature J Anaesthesiol Clin Pharmacol. Oct‑Dec 2019;35(4):441-452.
9. Lavand’homme P. Opioid‑free anaesthesia: pro: damned if you don’t use opioidsduring surgery. Er J Anaesthesiol 2019;26:247-249.
10. Thorell A, MacCormick A, Awad S. Guidelines for perioperative care in bariatric surgery: enhanced recovery after surgery (ERAS) society recommendations. World J Surg 2016 Sep; 40(9):2065-2083.
11. Suzan E, Pud D, Eisenberg E. A crucial administration timing separates between beneficial and counterproductive effects of opioids on postoperative pain. Pain 2018;159:1438-1440.
12. Guignard B, Bossard AE, Coste C, Sessler DI, Lebrault C, Alfonsi P et al. Acute opioid tolerance: intraoperative ramifentanil increases postoperative pain and morphine requirement. Anesthesiology 2000;93(2):409-417.
13. Fletcher D, MArtinez V. Opioid‑induced hyperalgesia in patients after surgery: a systematic review and meta‑analysis. Br J Anaesth 2014;112(6):991-1004.
14. Lavand’homme P. de Kock M. Waterloos H. Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery Anesthesiology 2005;103:813-820.
15. Wang L, Johnston B, Kaushal A, Cheng D, Zhu F, Martin J. Ketamine added to morphine or hydromorphone patient‑controlled analgesia for acute postoperative pain in adults: a systematic review and meta‑analysis of randomized trials. Can J Anesth. 2016;63:311-325.
16. Chaparro LE, Smith SA, Moore RA, Wiffen PJ, Gilron I. Pharmacotherapy for the prevention of chronic pain after surgery in adults. Cochrane Database of Systematic Reviews. 2013;7: Art.No.: CD 008307.
17. De Oliveira GS, Castro‑Alves LJ, Khan JH, McCarthy RJ. Perioperative systemic magnesium to minimize postoperative pain: a meta‑analysis of randomized controlled trials. Anesthesiology 2013;119(1):178-190.
18. Murphy JD, Paskaradevan J, Eisler LL et al. Analgesic efficacy of continuous intravenous magnesium infusion as an adjuvant to morphine for postoperative analgesia: a systematic review and meta‑analysis. Middle East J Anaesthesiol. 2013 Feb;22(1):11-20.
19. Mauermann E, Ruppen W, Bandschapp O. Different protocols used today to achieve total opiod‑ free general anesthesia without locoregional blocks. Best Practice & Research Clinical Anesthesiology. 2017;533-545.
20. Blaudszun G, Lysakowski C, Elia N, Tramér MR. Effect of Perioperative Systemic α2 Agonists on Postoperative Morphine Consumption and Pain Intensity. Anesthesiology. 2012;116:1312-1322.
21. Schnabel A, Meyer‑Friessem CH, Reichl SU, Zahn PK, Pogatzki‑Zahn EM. Is intraoperative dexmedetomidine a new option for postoperative pain treatment? A meta‑analysis of randomized controlled trials. Pain 2013;154:1140-1149.
22. Chen C, Huang P, Lai L, Luo C, Ge M, Hei Z et al. Dexmedetomidine improves gastrointentinal motility after laparoscopic resection of colorectal cancer: a randomized clinical trial. Medicine 2016;95(29):e4295.
23. Neil L, Patel A. Effect of dexmedetomidine versus fentanyl on haemodynamic response to patients undergoing elective laparoscopic surgery: a double‑blind randomized controlled study. JClinDiagnRes 2017;11:UCO1-4.
24. Sun Y, Li T, Wang N, Yun Y, Gan TJ. Perioperative Systemic Lidocaine for Postoperative Analgesia and Recovery after Abdominal Surgery: A Meta‑nalysis of Randomized Controlled Trials. Diseases of the Colon & Rectum. 2012;55(11):1183-1194.
25. De Oliveira GS, Castro‑Alves LJ, McCarthy RJ. Single Dose Systemic Acetaminophen to Prevent Postoperative Pain. A Meta‑analysis of Randomized Controlled Trials. Clin J Pain. 2015;31:86-93.
26. Martinez V, Beloeil H, Marret E, Fletcher D, Ravaud P, Trinquart L. Non‑opioid analgesics in adults after major surgery: systematic review with network meta‑analysis of randomized trials. BrJAnesth 2017;118:22-31.
27. Gobble RM, Hoang HLT, Kachniarz B, Orgill DP. Ketoralac Does Not Increase Perioperative Bleeding. A Meta‑analysis of Randomized Controlled Trials. Plast. Reconstr. Surg. 2014;133:741-755.
28. Saleh F, Jackson TD, Ambrosini L, Gnanasegaram JJ, Kwong J, Quereshy F et al. Perioperative Nonselective Non‑steroidal Anti‑inflammatory Drugs Are Not Associated with Anastomotic Leakage After Colorectal Surgery. J Gastrointest Surg. 2014; 18:1398-1404.
29. De Oliveira Jr GS, Almeida MD, Benzon HT, McCarthy RJ. Perioperative single dose systemic dexamethasone for postoperative pain: a meta‑analysis of randomized controlled trials Anesthesiology 2012;115:575-588.
30. Drummond GB, Bates A, Mann J, Arvind DK. Characterization of breathing patterns during patient‑controlled opioid analgesia. Br H Anaesth 2013;111:971-978.
31. Feld JM, Hoffman WE, Stechert MM, Hoffman IW, Ananda RC. Fentanyl or dexmedetomidine combined with desflurane for bariatric surgery. J Clin Anesth. 2006; 18:24-28.
32. Ziemann‑ Gimmel P, Goldfarb AA, Koppman J, Marema RT. Opioid‑free total intravenous anaesthesia reduces postoperative nausea and vomitting in bariatric surgery beyond triple prophylaxis. Br J Anaesth 2014;112:906-911.
33. Mulier JP, Wouters R, Dillemans B, Dekoc, M.A. randomized controlled, double‑blind trial evaluating the effect of opioid‑free versus opioid general anesthesia on postoperative pain and discomfort measured by the QoR40. J Clin Anesth Pain Med 2018;2:015.
34. Mulier JP, Dillemans B. Anesthetic factors affecting outcome after bariatric surgery, a retrospective levelled regrssion analysis. Obes Surg 2019;29:1841-1850.
35. Frauenknecht J, Kirkham KR, Jacot‑Guillarmod A, Albrecht E. Analgesic impact of intra‑ operative opioids vs. Opoid‑free anaeshesia: a systematic review and meta‑analysis. Anaesthesia 2019;74:651-662.
36. Montes A, Roca G, Sabate S, Lao JI, Navarro A, Cantillo J et al. Genetic and clinical factors associated with chronic postsurgical pain after hernia repair, hysterectomy, and thoracotomy: a two year multicenter cohort study. Anesthesiology 2015;122:1123-1141.
37. Van Gulik L, Ahlers SJ, van de Garde EM, Bruins P, van Boven WJ, Tibboel D, et al. Ramifentanil during cardiac surgery is associated with chronic thoracic pain 1 year after sternotomy. Br J Anaesth 2012;109(4):616-622.
38. Huxtable CA, Roberts LJ, Somogyi AA, MacIntyre PE. Acute pain management in opioid‑ tolerant patients: a growing challenge. Anaesth Intensive Care. 2011 Sep;39(5): 804-823.
39. Loftus RW. Yeager MP. Clark JA. Brown JR. Abdu WA. Sengupta DK. Beach ML. Intraoperative Ketamine Reduces Perioperative Opiate Consumption in Opiate‑dependent Patients with Chronic Back Pain Undergoing Back Surgery. Anesthesiology. 2010;113:639-646.
40. Forget P, De Kock M. Could anaesthesia, analgesia and sympathetic modulation affect neoplasic recurrence after surgery? A systematic review centred over the modulation of natural killer cells aktivity Ann Fr Anesth Reanim 2009;28(9):751-768.
41. Afsharimani B, Cabot P, Parat MO. Morphine and tumor growth and metastasis. Cancer Metastasis Rev 2011;30(2):225-238.
42. Boland JW, Pockley AG. Influence of opioids on immune function in patients with cancer pain: from bench to bedside. Br J Pharmacol 2018;175(14):2726-2736.
43. Forget P, Leonard D, Kartheuser A, De Kock M. Endpoint selection and unreported analgesic use may render oncologic studies inconclusive. Anesthesiology 2011;114(3):717.
44. Hontoir S, Saxena S, Gatto P, Khalife M, Ben Aziz AM, Paesmans M et al. Opioid‑free anesthesia: what about pain comfort? A prospective, randomized controlled trial. Acta Anaesthesiol Belg 2016;67(4):183-190.
45. Beiler B, Barraud D, Vigneron J, Demoré B. Physicochemical stability of an admixture of lidocaine and ketamine in polypropylene syringe used in opioid‑free anaesthesia. Eur J Hosp Pharm. 2020;27(e1):e79-83.
46. Christen Renée Lahner. Adult weight measurement: decoding the terminology used in literature, South African Journal of Clinical Nutrition.2019;32:2,28-31.
47. Arumugam SL, Lau CSM, Chamberlain RS: Use of preoperative gabapentin significantly reduces postoperative opioid consumption: A meta‑analysis. J Pain Res 2016;9:631-640.
48. Chou R, Gordon DB, de Leon‑Casasola OA, Rosenberg JM, Bickler S, Brennan T et al. Management of postoperative pain: A clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain 2016;17:131-157.
49. The European Society of Regional Anaesthesia and Pain Therapy: Prospect. Available at: https://esraeurope.org/prospect/. Accessed June 14,2020.
50. Jeon S, Lee HJ, Do W, Kim HK, Kwon JY, Hwang BY et al. Randomized controlled trial assessing the effectiveness of midazolam premedication as an anxiolytic, analgesic, sedative, and hemodynamic stabilizer. Medicine (Baltimore). 2018;97:e12187.
51. Marsh BWM, Morton N, Kenny GN. Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth. 1991;67:41-48.
52. Schnider TW, Minto CF, Gambus PL, Andresen C, Goodale DB,Shafer SL, Youngs EJ. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology. 1998;88:1170-1182.
53. Beloeil H, Garot M, Lebuffe G, Gerbaud A, Bila J, Cuvillon P et al. Balanced Opoid‑free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Ramifentanil for Major or Intermediate Noncardiac Surgery. Anesthesiology 2021;134:541-551.
54. Forget P. Opioid‑free anaesthesia. Why and how? A contextual analysis. Anaesth Crit Care Pain Med 38(2019):169-172.
Labels
Anaesthesiology, Resuscitation and Inten Intensive Care MedicineArticle was published in
Anaesthesiology and Intensive Care Medicine
2022 Issue 1
Most read in this issue
- The principles of opioid‑free anesthesia and postoperative analgesia, our experience in bariatric surgery
- Butyrylcholinesterase deficiency or “I remember intubation”
- Novel supraglottic airway devices in clinical practice
- Importance of intestinal microbiota in critically ill patients and possibilities of its influence