Our article after ten years: The practice of therapeutic mild hypothermia in cardiac arrest survivors in the Czech Republic

Czech version

Authors: R.- Škulec ^{1 4}; A. Truhlář ^3,5; J. Knor ²; J. Šeblová ^2,6,7; V.- Černý ^{1,4,8 10}
Authors‘ workplace: Klinika anesteziologie, perioperační a intenzivní medicíny, Univerzita J. E. Purkyně v Ústí nad Labem, Masarykova nemocnice v Ústí nad Labem ¹; Zdravotnická záchranná služba Středočeského kraje ²; Klinika anesteziologie, resuscitace a intenzivní medicíny, Univerzita Karlova, Lékařská fakulta v Hradci Králové, Fakultní nemocnice Hradec Králové ³; Fakulta zdravotnických studií, Univerzita J. E. Purkyně v Ústí nad Labem ⁴; Zdravotnická záchranná služba Královehradeckého kraje ⁵; Urgentní příjem, Oblastní nemocnice Kladno ⁶; Oddělení urgentního příjmu a LSPP dětí, Fakultní nemocnice Motol, Praha ⁷; Centrum pro výzkum a vývoj, Fakultní nemocnice Hradec Králové ⁸; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada ⁹; Technická univerzita v Liberci ¹⁰
Published in: Anest. intenziv. Med., 31, 2020, č. 4, s. 165-171
Category: Review Articles

Overview

In 2010, the results of a national survey on the use of therapeutic mild hypothermia in patients successfully resuscitated from Cardiac arrest or sudden circulatory arrest hospitalized in intensive care units in the Czech Republic were published. This article reflects the results of the survey in the context of knowledge at the time of publication and from the perspective of current knowledge.

Keywords:

therapeutic mild hypothermia – intensive care unit – survey

Sources

1. Skulec R, Truhlar A, Knor J, Seblova J, Cerny V. The practice of therapeutic mild hypothermia in cardiac arrest survivors in the Czech republic. Minerva Anestesiol. 2010; 76(8): 617–623.

2. Edgren E, Hedstrand U, Kelsey S, Sutton‑Tyrrell K, Safar P. Assessment of neurological prognosis in comatose survivors of cardiac arrest. BRCT I Study Group. Lancet. 1994; 343(8905): 1055–1059.

3. Škulec R, Truhlář A, Šeblová J, Knor J, Dostál P, Černý V. In‑hospital therapeutic hypothermia in cardiac arrest survivors: Growing implementation in the Czech Republic (PRE‑COOL 2: Hospital survey 2008). Anesteziol a Intenziv Med. 2010; 21(6): 317–323.

4. Nolan JP, Neumar RW, Adrie C, Aibiki M, Berg RA, Böttiger BW, et al. Post‑ cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Coun. Resuscitation. 2008; 79(3): 350–379.

5. Skulec R, Truhlar A, Ostadal P, Telekes P, Knor J, Tichacek M, et al. Current cooling methods for induction of mild hypothermia in cardiac arrest survivors. Vnitřní lékařství. 2009; 55(11): 1060–1069.

6. Erecinska M, Thoresen M, Silver IA. Effects of hypothermia on energy metabolism in Mammalian central nervous system. J Cereb Blood Flow Metab. 2003; 23(5): 513–530.

7. Busto R, Globus MY, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. Effect of mild hypothermia on ischemia‑ induced release of neurotransmitters and free fatty acids in rat brain. Stroke. 1989; 20(7): 904–910.

8. Globus MY, Busto R, Lin B, Schnippering H, Ginsberg MD. Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem. 1995; 65(3): 1250–1256.

9. Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002; 346(8): 549–556.

10. Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, et al. Treatment of comatose survivors of out‑ of‑hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002; 346(8): 557–563.

11. Testori C, Sterz F, Behringer W, Haugk M, Uray T, Zeiner A, et al. Mild therapeutic hypothermia is associated with favourable outcome in patients after cardiac arrest with non‑shockable rhythms. Resuscitation. 2011; 82(9): 1162–1167.

12. Behringer W, Arrich J, Holzer M, Sterz F. Out‑of‑hospital therapeutic hypothermia in cardiac arrest victims. Scand J Trauma Resusc Emerg Med. 2009; 17: 52.

13. Arrich J; European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group. Clinical application of mild therapeutic hypothermia after cardiac arrest. Crit Care Med. 2007; 35(4): 1041–1047.

14. Skulec R, Kovarnik T, Dostalova G, Kolar J, Linhart A. Induction of mild hypothermia in cardiac arrest survivors presenting with cardiogenic shock syndrome. Acta Anaesthesiol Scand. 2008; 52(2): 188–194.

15. Skulec R, Truhlar A, Seblova J, Dostal P, Cerny V. Pre‑hospital cooling of patients following cardiac arrest is effective using even low volumes of cold saline. Crit Care. 2010; 14(6): R231.

16. Skulec R, Kovarnik T, Belohlavek J, Dostalova G, Kolar J, Linhart A, et al. Overcooling during mild hypothermia in cardiac arrest survivors--phenomenon we should keep in mind. Vnitřní lékařství. 2008; 54(6): 609–614.

17. Nielsen N, Hovdenes F, Nilsson F, Rubertsson S, Stammet P, Sunde K, et al. Outcome, timing and adverse events in therapeutic hypothermia after out‑of‑hospital cardiac arrest. Acta Anaesthesiol Scand. 2009; 53(7): 926–934.

18. Hovdenes J, Laake JH, Aaberge L, Haugaa H, Bugge JF. Therapeutic hypothermia after out‑of‑hospital cardiac arrest: experiences with patients treated with percutaneous coronary intervention and cardiogenic shock. Acta Anaesthesiol Scand. 2007; 51(2): 137–142.

19. Sunde K, Pytte M, Jacobsen D, Mangschau A, Jensen LP, Smedsrud C, et al. Implementation of a standardised treatment protocol for post resuscitation care after out‑of‑hospital cardiac arrest. Resuscitation. 2007; 73(1): 29–39.

20. Tømte O, Andersen GØ, Jacobsen D, Drægni T, Auestad B, Sunde K. Strong and weak aspects of an established post‑resuscitation treatment protocol‑A five‑year observational study. Resuscitation. 2011; 82(9): 1186–1193.

21. Werling M, Thorén A‑B, Axelsson C, Herlitz J. Treatment and outcome in post‑resuscitation care after out‑of‑hospital cardiac arrest when a modern therapeutic approach was introduced. Resuscitation. 2007; 73(1): 40–45.

22. Kim F, Olsufka M, Longstreth WT Jr, Maynard C, Carlbom D, Deem S, et al. Pilot randomized clinical trial of prehospital induction of mild hypothermia in out‑of‑hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline. Circulation. 2007; 115(24): 3064–3070.

23. Castrén M, Nordberg P, Svensson L, Taccone F, Vincent JL, Desruelles D, et al. Intra‑arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre‑ROSC IntraNasal Cooling Effectiveness). Circulation. 2010; 122(7): 729–736.

24. Nolan JP, Deakin CD, Soar J, Böttiger BW, Smith G. European Resuscitation Council guidelines for resuscitation 2005. Section 4. Adult advanced life support. Resuscitation. 2005; 67 Suppl 1: S39–86.

25. Deakin CD, Nolan JP, Soar J, Sunde K, Koster RW, Smih GB, et al. European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support. Resuscitation. 2010; 81(10): 1305–1352.

26. Hoedemaekers CW, Ezzahti M, Gerritsen A, van der Hoeven JG. Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: a prospective intervention study. Crit Care. 2007; 11(4): R91.

27. Finley Caulfield A, Rachabattula S, Eyngorn I, Hamilton SA, Kalimuthu R, Hsia AW, et al. A comparison of cooling techniques to treat cardiac arrest patients with hypothermia. Stroke Res Treat. 2011; 2011: 1–6.

28. Zhou J, Poloyac SM. The effect of therapeutic hypothermia on drug metabolism and response: cellular mechanisms to organ function. Expert Opin Drug Metab Toxicol. 2011; 7(7): 803–816.

29. Takino M, Okada Y. Hyperthermia following cardiopulmonary resuscitation. Intensive Care Med. 1991; 17(7): 419–420.

30. Takasu A, Saitoh D, Kaneko N, Sakamoto T, Okada Y. Hyperthermia: is it an ominous sign after cardiac arrest? Resuscitation. 2001; 49(3): 273–277.

31. Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, et al. Targeted Temperature Management at 33 °C versus 36 °C after Cardiac Arrest. N Engl J Med. 2013; 369(23): 2197–2206.

32. Nolan JP, Soar J, Cariou A, Cronberg T, Moulaert VLM, Deakin CD, et al. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines for Post‑resuscitation Care 2015: Section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015. Resuscitation. 2015; 95: 202–222.

33. Lascarrou JB, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, et al. Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm. N Engl J Med. 2019; 381(24): 2327–2337.

34. Kämäräinen A, Hoppu S, Silfvast T, Virkkunen I. Prehospital therapeutic hypothermia after cardiac arrest--from current concepts to a future standard. Scand J Trauma Resusc Emerg Med. 2009; 17(August): 53.

35. Kämäräinen A, Virkkunen I, Tenhunen J, Yli‑Hankala A, Silfvast T. Prehospital induction of therapeutic hypothermia during CPR: a pilot study. Resuscitation. 2008; 76(3): 360–363.

36. Bernard SA, Smith K, Cameron P, Masci K, Taylor DM, Cooper DJ, et al. Induction of therapeutic hypothermia by paramedics after resuscitation from out‑of‑hospital ventricular fibrillation cardiac arrest: a randomized controlled trial. Circulation. 2010; 122(7): 737–742.

37. Bernard SA, Smith K, Cameron P, Masci K, Taylor DM, Cooper DJ, et al. Induction of prehospital therapeutic hypothermia after resuscitation from nonventricular fibrillation cardiac arrest*. Crit Care Med. 2012; 40(3): 747–753.

38. Kim F, Nichol G, Maynard C, Hallstrom A, Kudenchuk PJ, Rea T, et al. Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial. JAMA. 2014; 311(1): 45–52.

39. Škulec R, Šeblová J, Truhlář A. Konsenzuální stanovisko pro cílenou regulaci tělesné teploty v přednemocniční neodkladné péči u nemocných po mimonemocniční náhlé zástavě oběhu. Urgentní medicína. 2017; 20(2): 28–29.

40. Calabró L, Bougouin W, Cariou A, De Fazio C, Skrifvars M, Soreide E, et al. Effect of different methods of cooling for targeted temperature management on outcome after cardiac arrest: a systematic review and meta‑analysis. Crit Care. 2019; 23(1): 285.

41. Balík M, Bělohlávek J, Beneš J, Černý V, Cvachovec K, Drábek T, et al. Cílená regulace tělesné teploty: konsenzuální stanovisko mezioborové pracovní skupiny. Anest intenziv Med. 2020; 31(1–2): 59–63.