Some aspects of molecular biology in critically ill patients in the context of current laboratory medicine

Czech version

Authors: M. Průcha; S. Peková; L. Sedláčková
Authors‘ workplace: Oddělení klinické biochemie, hematologie a imunologie, Nemocnice Na Homolce, Praha
Published in: Anest. intenziv. Med., 19, 2008, č. 1, s. 5-8
Category: Intensive Medicine

Overview

Biomarkers are recognized as objective indicators of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention.

Sepsis is a multifactorial disease distinguished by the paucity of diagnostic tests (biomarkers) available. New biomarkers allow for a better understanding of the pathogenesis of diseases and better stratification of patients in connection with improved clinical decision making, diagnosis and treatment. New technologies – genomics and proteomics – enable multiplex detection and evaluation of biomarkers. The goal of the diagnostics at present is the implementation of new technologies and molecular approaches into routine clinical practice with emphasis on therapeutic consequences that could make “personalized medicine“ a real option.

Keywords:
biomarkers – genomics – molecular biology – proteomics – sepsis

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