Asociace TNF-α -308G>A polymorfizmu s citlivostí na karcinom děložního čípku a prsu – systematický přehled a metaanalýza

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Autoři: Meraj Farbod ¹; Mojgan Zarchi Karimi ^2,3; Naeimeh Heiranizadeh ⁴; Neda Shalamzari Seifi ⁵; Javad Bafghi Mohammad Akbarian ⁶; Hossein Mohammad Jarahzadeh ⁷; Hossein Neamatzadeh ^8,9
Působiště autorů: Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran ¹; Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ²; Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran ³; Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ⁴; Department of Emergency Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran ⁵; Department of Healthcare Management, Bam University of Medical Sciences, Bam, Iran ⁶; Department of Anesthesiology and Critical Care, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ⁷; Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ⁸; Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ⁹
Vyšlo v časopise: Klin Onkol 2019; 32(3): 170-180
Kategorie: Přehled
doi: https://doi.org/10.14735/amko2019170

Souhrn

Východiska: Bylo provedeno několik studií týkajících se souvislosti TNF-α -308G>A s rizikem karcinomu děložního čípku (cervical cancer – CC) a prsu (breast cancer – BC). Nicméně jejich závěry nebyly konzistentní. Proto jsme provedli komplexní metaanalýzu, aby bylo možné souvislost shodněji zhodnotit ze všech příslušných případových kontrolních studiích.

Metody: Do 1. února 2019 jsme systematicky prohledali PubMed, Google Scholar a databázi Cochrane Library. Míra rizika (OR) s 95% intervalem spolehlivosti (CI) byla vypočtena pomocí modelu s pevnými nebo náhodnými efekty.

Výsledky: V této metaanalýze bylo vybráno celkem 40 případových studií zahrnujících 20 studií s 4 780 případy a 4 620 kontrolami na CC a 20 studií s 12 390 případy a 14 910 kontrolami na BC. Souhrnné výsledky ukázaly, že TNF-α -308G>A polymorfizmus byl významně spojen se zvýšeným rizikem CC (A vs. G: OR 1,277; 95% CI 1,104–1,477; p = 0,001; OR 1,333; 95% CI 1,062–1,674; p = 0,013; AG vs. GG: OR 1,307; 95% CI 1,064–1,605; p = 0,011 a AA + AG vs. GG: 95% CI 1,104–1,587; p = 0,002) a BC (AA vs. AG + GG: OR 0,094; 95% CI 0,058–0,152, p ≤ 0,001). Ve stratifikovaných analýzách podle etnicity byl polymorfizmus TNF-α -308G>A významně spojen s rizikem CC (u kavkazské a africké populace) a BC (u bělochů a Asiatů).

Závěr: Naše výsledky ukázaly, že polymorfizmus TNF-α -308G>A může být rizikovým faktorem karcinomu děložního čípku a BC v závislosti na etnicitě.

Autoři děkují Sahel Khajehnoori z Mother and Newborn Health Research Center za pomoc při revizi článku.

Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.

Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do biomedicínských časopisů.

Obdrženo: 10. 2. 2019

Přijato: 5. 3. 2019

Klíčová slova:

karcinom děložního čípku – karcinom prsu – gen TNF-α – polymorfizmus – metaanalýza

Zdroje

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