Hantavirus causing fatal haemorrhagic fever in the Czech Republic

Česká verze

Authors: H. Zelená ^1,2; M. Rumlerová ³; K. Kodras ⁴; P. Beroušková ⁵; J. Mrázek ¹; J. Smetana ²
Authors place of work: Zdravotní ústav se sídlem v Ostravě, Národní referenční laboratoř pro arboviry ¹; Univerzita Obrany Hradec Králové, Fakulta vojenského zdravotnictví ²; Oblastní nemocnice Kladno, Klinická laboratoř ³; Oblastní nemocnice Kladno, Anesteziologicko-resuscitační oddělení ⁴; Oblastní nemocnice Kladno, Oddělení patologické anatomie ⁵
Published in the journal: Epidemiol. Mikrobiol. Imunol. 66, 2017, č. 3, s. 149-152
Category: Krátké sdělení

Summary

Hantaviruses are RNA viruses of the family Bunyaviridae. Their hosts are mammals of the orders rodents (voles, rats, mice), insectivores (shrews, moles), and chiroptera (bats). Hantaviruses are present in many areas of Europe, the Americas, Asia, and Africa. In the Czech Republic, the occurrence of five species of hantaviruses has been reported (Dobrava/Belgrade, Puumala, Tula, Seewis, and Asikkala), with the first three of them causing human diseases. Although the course of hantavirus infections can be very serious, there is a low awareness of these diseases, even among health professionals, and hantavirus is often not considered in the diagnosis. A case history is reported of a patient who developed hantavirus haemorrhagic fever with renal syndrome (HFRS) with fatal outcome. The patient presented with typical clinical signs, but the correct diagnosis was only made at post mortem.

KEYWORDS:
hantaviruses – haemorrhagic fever with renal syndrome – Dobrava/Belgrade

Zdroje

1. Jonsson CB, Figueiredo LT, Vapalahti O. A global perspective on hantavirus ecology, epidemiology, and disease. Clinical Microbiology Reviews, 2010;23: 412–441.

2. Hiertqvist M, Klein SL, Ahlm C, et al. Mortality Rate Patterns for Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. Emerg Infect Dis, 2010;16: 1584–1586.

3. Heyman P, Ceianu CS, Christova I, et al. A five-year perspective on the situation of haemorrhagic fever with renal syndrome and status of the hantavirus reservoirs in Europe, 2005–2010. Euro Surveill, 2011;16(36): pii=19961. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19961.

4. Klempa B, Avsic-Zupanc T, Clement J, et al. Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics. Arch Virol, 2013;158: 521–529.

5. Lundkvist Å, Verner-Carlsson J, Plyusnina A, et al. Pet rat harbouring Seoul hantavirus in Sweden, June 2013. Euro Surveill, 2013;18(27): pii=20521. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20521.

6. Reynes J, Carli D, Boukezia N, et al. Tula hantavirus infection in a hospitalised patient, France, June 2015. Euro Surveill, 2015;20(50): pii=30095. DOI: http://dx.doi.org/10.2807/1560-7917.

7. Vrbovská V, Chalupa P, Straková P, et al. Onemocnění člověka způsobené hantaviry – stále opomíjené zoonózy? Epidemiol mikrobiol imunol, 2015;64: 188–196.

8. EPIDAT: informační systém infekčních nemocí [online]. Praha: Státní zdravotní ústav [cit. 2017-02-20] Available online: http://www.szu.cz/publikace/data/vybrane-infekcni-nemoci-v-cr-v-letech-2006-2016-absolutne.

9. Kruger DH, Figueiredo LT, Song JW, et al. Hantaviruses – Globally emerging pathogens. J Clin Virol, 2015;64: 128–136.

10. Vaheri A, Strandin T, Jaaskelainen AJ, et al. Pathophysiology of a severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant. Antiviral Res, 2014;111: 23–25.