#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Myxoid tumors of soft tissues


Authors: Karel Veselý
Authors place of work: AeskuLab patologie, k. s. - Laboratoř Brno, Brno.
Published in the journal: Čes.-slov. Patol., 53, 2017, No. 2, p. 71-80
Category: Přehledový článek

Summary

Myxoid tumours of soft tissue represent a heterogeneous spectrum of lesions with variable biological behaviour, from completely benign to highly aggressive malignancies. Myxoid tumours share abundant myxoid extracellular matrix, overlapping histopathologic features and immunohistochemical findings, with resulting diagnostic problems. This review article attempts to give the most complete list possible, with the characterization of gross and microscopic features, relevant immunohistochemical and molecular biology findings and to outline differential diagnosis.

Keywords:
myxoid tumours – soft tissue – myxoma – sarcoma


Zdroje

1. Pittman ME, Montgomery EA. Distinctive clinicopathologic features of the common myxoid soft-tissue lesions. Diagn Histopathol 2015; 21(11): 438–444.

2. Allen PW. Myxoma is not a single entity: a review of the concept of myxoma. Ann Diagn Pathol 2000; 4(2): 99-123.

3. Willems SM, Schrage YM, Baelde JJ et al. Myxoid tumours of soft tissue: the so-called myxoid extracellular matrix is heterogeneous in composition. Histopathology 2008; 52(4): 465-474.

4. Downs-Kelly E, Goldblum JR, Patel RM et al. The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms. Am J Surg Pathol 2008; 32(1): 8-13.

5. Graadt van Roggen JF, Hogendoorn PC, Fletcher CD. Myxoid tumours of soft tissue. Histopathology 1999; 35(4): 291-312.

6. Zou Y, Billings SD. Myxoid cutaneous tumors: a review. J Cutan Pathol 2016; 43(10): 903-918.

7. Ashby-Richardson H, Rogers GS, Stadecker MJ. Superficial acral fibromyxoma: an overview. Arch Pathol Lab Med 2011; 135(8): 1064-1066.

8. Fetsch JF, Laskin WB, Miettinen M. Nerve sheath myxoma: a clinicopathologic and immunohistochemical analysis of 57 morphologically distinctive, S-100 protein- and GFAP-positive, myxoid peripheral nerve sheath tumors with a predilection for the extremities and a high local recurrence rate. Am J Surg Pathol 2005; 29(12): 1615-1624.

9. Wang GY, Nazarian RM, Zhao L et al. Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions: comparison with cellular neurothekeoma. Pathology 2017; 49(1): 44-49.

10. Sutton BJ, Laudadio J. Aggressive angiomyxoma. Arch Pathol Lab Med 2012; 136(2): 217-221.

11. Kilpatrick SE, Doyon J, Choong PF, Sim FH, Nascimento AG. The clinicopathologic spectrum of myxoid and round cell liposarcoma. A study of 95 cases. Cancer 1996; 77(8): 1450-1458.

12. Hollmann TJ, Hornick JL. INI1-deficient tumors: diagnostic features and molecular genetics. Am J Surg Pathol 2011; 35(10): e47-63.

13. Benini S, Cocchi S, Gamberi G et al. Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. J Mol Diagn 2014; 16(3): 314-323.

14. Odem JL, Oroszi G, Bernreuter K et al. Deceptively benign low-grade fibromyxoid sarcoma: array-comparative genomic hybridization decodes the diagnosis. Hum Pathol 2013; 44(1): 145-150.

15. Fetsch JF, Laskin WB, Miettinen M. Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. Hum Pathol 2001; 32(7): 704-714.

16. Yasuda T, Kanamori M, Nobukiyo M, Nogami S, Hori T, Kimura T. Acral myxoinflammatory fibroblastic sarcoma of the foot. J Exp Clin Cancer Res 2007; 26(2): 277-280.

17. Michal M, Kazakov DV, Hadravský L, Kinkor Z, Kuroda N, Michal M. High-grade myxoinflammatory fibroblastic sarcoma: a report of 23 cases. Ann Diagn Pathol 2015; 19(3): 157-163.

18. Michal M, Kazakov DV, Hadravský L, et al. Pleomorphic hyalinizing angiectatic tumor revisited: all tumors manifest typical morphologic features of myxoinflammatory fibroblastic sarcoma, further suggesting 2 morphologic variants of a single entity. Ann Diagn Pathol 2016; 20: 40-43.

19. Zreik RT, Carter JM, Sukov WR et al. TGFBR3 and MGEA5 rearrangements are much more common in “hybrid” hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas: a morphological and fluorescence in situ hybridization study. Hum Pathol 2016; 53: 14-24.

20. Thway K, Nicholson AG, Lawson K et al. Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a new tumor entity. Am J Surg Pathol 2011; 35(11): 1722-1732.

21. Hoang LN, Aneja A, Conlon N, et al. Novel high-grade endometrial stromal sarcoma: a morphologic mimicker of myxoid leiomyosarcoma. Am J Surg Pathol 2017; 41(1): 12-24.

22. Patton A, Page R, Googe PB, King R. Myxoid atypical fibroxanthoma: a previously undescribed variant. J Cutan Pathol 2009; 36(11): 1177-1184.

23. Dantey K, Cooper K. Myxoid solitary fibrous tumour: instructive case and literature review. Diagn Histopathol 2013; 19(2): 67–70.

24. Burch DM, Tavassoli FA. Myxoid leiomyosarcoma of the uterus. Histopathology 2011; 59(6): 1144-1155.

25. Krane JF, Bertoni F, Fletcher CD. Myxoid synovial sarcoma: an underappreciated morphologic subset. Mod Pathol 1999; 12(5): 456-462.

26. Rubin BP, Fletcher CD. Myxoid leiomyosarcoma of soft tissue, an underrecognized variant. Am J Surg Pathol 2000; 24(7): 927-936.

27. Flucke U, Hulsebos TJ, van Krieken JH, Mentzel T. Myxoid epithelioid sarcoma: a diagnostic challenge. A report on six cases. Histopathology 2010; 57(5): 753-759.

28. Wang L, Wang G, Wang L, Gao T. Myxoid intravascular fasciitis. J Cutan Pathol 2011; 38(1): 63-66.

29. Shin C, Low I, Ng D, Oei P, Miles C, Symmans P. USP6 gene rearrangement in nodular fasciitis and histological mimics. Histopathology 2016; 69(5): 784-791.

30. Bohman SL, Goldblum JR, Rubin BP, Tanas MR, Billings SD. Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum. Pathology 2014; 46(3): 199-204.

31. Rodriguez FJ, Folpe AL, Giannini C, Perry A. Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol 2012; 123(3): 295-319.

32. Gable AD, Clark SH, Magro CM. Myxoid variant of anaplastic large cell lymphoma involving the skin: a case report. J Cutan Pathol 2012; 39(8): 787-790.

33. Inoue T, Misago N, Narisawa Y. Metastatic myxoid melanoma with partial regression of the primary lesion. J Cutan Pathol 2007; 34(6): 508-512.

34. Yang A, Hanley A, Velazquez EF, Cassarino DS. Primary cutaneous myxoid spindle cell squamous cell carcinoma: a clinicopathologic study and review of the literature. J Cutan Pathol 2010; 37(4): 465-474.

35. Shia J, Qin J, Erlandson RA et al. Malignant mesothelioma with a pronounced myxoid stroma: a clinical and pathological evaluation of 19 cases. Virchows Arch 2005; 447(5): 828-834.

Štítky
Patologie Soudní lékařství Toxikologie

Článek vyšel v časopise

Česko-slovenská patologie

Číslo 2

2017 Číslo 2

Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

Svět praktické medicíny 3/2024 (znalostní test z časopisu)
nový kurz

Kardiologické projevy hypereozinofilií
Autoři: prof. MUDr. Petr Němec, Ph.D.

Střevní příprava před kolonoskopií
Autoři: MUDr. Klára Kmochová, Ph.D.

Aktuální možnosti diagnostiky a léčby litiáz
Autoři: MUDr. Tomáš Ürge, PhD.

Závislosti moderní doby – digitální závislosti a hypnotika
Autoři: MUDr. Vladimír Kmoch

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#