Unusual lung finding of massive alveolar filling with foamy macrophages in congenital epidermolysis bullosa after amnion fluid aspiration in 15-day-old newborn without any clinical signs of respiratory impairment

Česká verze

Authors: Daniel Farkaš ¹; Marián Švajdler ml. ²; Lucia Fröhlichová ²; Jana Šprláková ³; Silvia Farkašová Iannaccone ⁴; Zoltán Szép ⁵; Oľga Nyitrayová ⁵
Authors place of work: Bioptická laboratoř s. r. o., Plzeň, Česká Republika a Oddelenie patológie, Univerzitná nemocnica Louisa Pasteura, Košice, Slovenská Republika ; Úrad pre dohľad nad zdravotnou starostlivosťou, SLaPA pracovisko, Košice ¹; Šiklův ústav patologie, Univerzita Karlova Praha, Lékařská fakulta Plzeň, Česká Republika ²; Detská fakultná nemocnica, Košice ³; Ústav súdneho lekárstva UPJŠ LF, Košice ⁴; Cytopathos s. r. o., Bratislava ⁵
Published in the journal: Čes.-slov. Patol., 51, 2015, No. 2, p. 89-93
Category: Původní práce

Summary

Epidermolysis bullosa represents a group of mechanobullous diseases which are most commonly genetically determined. We describe the case of a 15-day-old female newborn with congenital epidermolysis bullosa which was inflicted on aproximately 1/3 of her skin surface, who died because of incorrigible sepsis with multiorgan failure. The main topic of our report is a description of an unusual pulmonary finding of massive alveolar filling with foamy macrophages after amnion fluid aspiration, which contained a excessive amount of desquamated epidermal cells. Introduced case shows outstanding discrepancy of negative clinical finding on one side and massive histopathological finding on the other.

Keywords:
epidermolysis bullosa –⁠ foamy alveolar macrophages –⁠ amniotic fluid aspiration

Zdroje

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