Current status of urinary cytology in the evaluation of bladder neoplasms

Česká verze

Authors: Ondrej Ondič ^1,2 ; Robert Slunéčko ^1,2; Marián Švajdler - ml. ^{1 3}
Authors place of work: Šiklův ústav patologie, Univerzita Karlova Praha, lékařská fakulta Plzeň a FN Plzeň ¹; Bioptická laboratoř s. r. o., Plzeň ²; Oddelenie patológie, Univerzitná nemocnica Louisa Pasteura, Košice ³
Published in the journal: Čes.-slov. Patol., 50, 2014, No. 4, p. 142-145
Category: Přehledové články - Uropatologie

Summary

Urine cytology is a reliable method for identification and follow up of the patients who develop high-grade urothelial carcinoma. Reactive changes of superficial and intermediate urothelial cells cytologically often mimic low grade urothelial carcinoma. This is the cause of relatively high number of false positive and false negative results. Diagnostic accuracy can be improved introducing different procedures for material handling namely cytospin and liquid based cytology and new diagnostic protocols such as FISH for chromosomal aberrations or mRNA and miRNA analysis. Most recently Next Generation Sequencing for DNA analysis was applied. Availability of clinical information improves the diagnostic accuracy and shortens the time to diagnosis.

Keywords:
cytology - urine - urothelial carcinoma – LBC

Zdroje

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