New Aspects of Tumor Pathobiology

Česká verze

Authors: M. Ludvíková ¹; M. Pešta ^2,3; L. Holubec jr. ³; D. Kalfeřt ⁴
Authors place of work: Ústav biologie LF UK Plzeň, Ústav patologie 1. LF UK a VFN Praha, Fakulta zdravotnických studií ZČU, Plzeň ¹; II. interní klinika a Centrální laboratoř pro imunoanalýzu LF UK a FN, Plzeň ²; Onkologické a radioterapeutické oddělení LF UK a FN, Plzeň ³; Klinika ušní, nosní a krční LF UK a FN, Hradec Králové ⁴
Published in the journal: Čes.-slov. Patol., 45, 2009, No. 4, p. 94-99
Category: Přehledový článek

Summary

Several biological principles such as epigenetic changes, RNA interference, epithelial-mesenchymal transition, and cancer stem cell formation have been recently connected to the pathobiology of tumors. All these phenomena have, along with genetic changes, a significant impact on the neoplastic transformation and/or tumor progression. Authors report a review of the above mentioned “nongenetic“ processes and their effect on the neoplastic transformation, and the appearance, behavior, prognosis, and therapy of tumors. Future diagnostic and therapeutic perspectives are also discussed.

Key words:
tumor pathobiology – epigenetic changes – RNA interference – epithelial-mesenchymal transition – cancer stem cells

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